32263-14-2

Basic information

• Product Name: 4-HYDROXY-3-METHOXY-5-METHYLBENZENECARBALDEHYDE
• Synonyms: 4-HYDROXY-3-METHOXY-5-METHYLBENZENECARBALDEHYDE;4-hydroxy-3-methoxy-5-methylbenzaldehyde
• CAS NO: 32263-14-2
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Mol File: 32263-14-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-HYDROXY-3-METHOXY-5-METHYLBENZENECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-3-METHOXY-5-METHYLBENZENECARBALDEHYDE(32263-14-2)
• EPA Substance Registry System: 4-HYDROXY-3-METHOXY-5-METHYLBENZENECARBALDEHYDE(32263-14-2)

Safety Data

• Hazardous Substances Data: 32263-14-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 13, p. 677, 1983 DOI: 10.1080/00397918308060349

Upstream product

• 67-66-3 chloroform 
• 2896-67-5 2-methyl-6-methoxyphenol 
• 121-33-5 vanillin 
• 87743-10-0 3-((dimethylamino)methyl)-4-hydroxy-5-methoxybenzaldehyde 
• 60824-65-9 (4-Hydroxy-3-methoxy-5-methylbenzyl)-methylaether 
• 2896-66-4 2-methoxy-4,6-dimethylphenol 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 87743-11-1 Acetic acid 2-acetoxymethyl-4-formyl-6-methoxy-phenyl ester 
• 82628-68-0 3,4-dihydroxy-5-methylbenzaldehyde 
• 74-88-4 methyl iodide 
• 100-97-0 hexamethylenetetramine 
• 37987-18-1 4-Hydroxy-3-methoxy-5-methyl-benzylalkohol 
• 28276-04-2 3-(chloromethyl)-4-hydroxy-5-methoxybenzaldehyde 

Downstream Products

• 46274-23-1 2-(3,4-dimethoxy-5-methylphenyl)ethan-1-amine 
• 3153-96-6 1,2-dimethoxy-3-methyl-5-(2-nitro-vinyl)benzene 
• 80547-80-4 3,4-dimethoxy-5-methylbenzaldehyde 
• 1415689-41-6 C₁₇H₁₆ClFN₂O₆S 
• 1415689-37-0 C₁₈H₁₈ClFN₂O₅S 

Relevant articles and documents

Preparation method of 5-methyl vanillin

The invention relates to a preparation method of 5-methyl vanillin, which comprises the following steps: 1) by using ortho vanillin as a raw material, carrying out hydrogenation reduction reaction under the action of a hydrogenation catalyst to obtain 6-m

Application of conjugate of polyethylene glycol and local anesthetic to non-narcotic analgesia

The invention discloses application of a conjugate of polyethylene glycol and local anesthetic to non-narcotic analgesia. The local anesthetic is made into a prodrug or a sustained release preparation, wherein high-molecular polymers such as polyethylene glycol in the prodrug are covalently bonded with local anesthetic, and auxiliary materials with a sustained release function in the sustained release preparation are covalently bonded with the local anesthetic. After application of the conjugate, anesthesia and analgesia effects are not achieved until release of free local anesthetic, and an analgesia effect is achieved after release of the free local anesthetic. Due to low release speed of the prodrug or the sustained release preparation of the local anesthetic, drug concentration can bestably and enduringly kept in an effective concentration range of non-narcotic analgesia, long-acting non-narcotic analgesia effects can be achieved while remarkable reduction of clinical untoward effects of the local anesthetic and reduction of dosing frequency are realized, drug effectiveness is improved, and a clinical application range of the local anesthetic is expanded.

Magnetic nano-structured cobalt-cobalt oxide/nitrogen-doped carbon material as an efficient catalyst for aerobic oxidation of p-cresols

Efficient aerobic oxidation has been developed for the selective preparation of a sequence of valuable p-hydroxybenzaldehydes from corresponding p-cresols, using a new magnetically separable catalyst of nano-structured cobalt-cobalt oxide/nitrogen-doped carbon (CoOx@CN) material. CoOx@CN showed high activity for the 2-methoxy-4-cresol oxidation to vanillin, giving great yield (90%) and with good turnover number (210), as well as other p-cresols in good to great yields. The catalytic performance was investigated and related to the structural, chemical and magnetic properties which determined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM). The effects of base to substrate molar ratio, catalyst concentration, temperature, and solvent on the conversion and selectivity patterns also have been studied. The investigation revealed that remarkable catalytic properties of CoOx@CN could be ascribed to the active species cobalt oxide, doped nitrogen and porous carbon with large surface area. The size of the catalyst is a key factor for catalyst performance. The ferromagnetic property of catalyst enables to recycle easily by an external magnetic field and reuse six successive times without significant activity loss.

Tetrahydrocoptisine derivative and applications thereof

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2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF

Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions

A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcohols and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds. The ligand- and additive-free Cu(OAc)2-catalyzed atmospheric oxidation mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodology is expected to be of significant value for both fundamental research and practical applications.

Environmentally friendly and highly efficient Co(OAc)2-catalyzed aerobic oxidation to access 2,6-di-electron-donating group substituted 4-hydroxybenzaldehydes

A highly efficient and green aerobic oxidation has been developed for selectively preparing a series of valuable 2,6-dialkyl-, dialkoxyl-, and alkoxylalkyl-substituted 4-hydroxybenzaldehydes from corresponding 4-cresols in good to excellent yields, using a catalytic system of Co(OAc)24H2O (1.0 mol%)-NaOH (1.0 equiv)-O2(1.0 atm) in aqueous ethylene glycol (EG/H2O = 20/1, v/v) at 50 °C. Furthermore, a plausible mechanism was proposed for the direct oxyfunctionalization of the aromatic methyl group into the aldehyde group.

A concise route to 3-hydroxy-4-methoxy-5-methylbenzaldehyde derivative

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