2828-18-4Relevant academic research and scientific papers
Rh(I)-Catalyzed olefin hydroarylation with electron-deficient perfluoroarenes
Sun, Zhong-Ming,Zhang, Jing,Manan, Rajith S.,Zhao, Pinjing
supporting information; experimental part, p. 6935 - 6937 (2010/08/06)
Assisted by a partially aqueous media, a catalyst system of [Rh(cod)(OH)]2 and DPPBenzene ligand effectively promotes direct conjugate additions by perfluoroarenes. This formal C-H alkylation process represents a rare example of olefin hydroarylation with electron-deficient arenes. The catalyst system can be modified to selectively form the corresponding olefination products under anhydrous conditions.
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors
Voelker, Troy,Xia, Haiji,Fandrick, Keith,Johnson, Robert,Janowsky, Aaron,Cashman, John R.
experimental part, p. 2047 - 2068 (2009/06/06)
Enhancement of 5-hydroxytryptamine (5-HT, serotonin) neurotransmission is a viable means of treating depression. On the basis of this observation, agents that inhibit re-uptake of 5-HT were prepared based on (-)-cocaine and aryltropanes as lead compounds
MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS
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Page/Page column 90, (2010/10/20)
Disclosed are agents having pharmacological activity against cellular receptors and intracellular singaling, particularly receptors and sigaling pathways of central nervous system (CNS) neurotransmitters. Also disclosed are related methods and compositions for the treatment or prevention of diseases or disorders using the agents.
