28281-76-7

Basic information

• Product Name: 5-Methoxy-isobenzofuran-1,3-dione
• Synonyms: 5-Methoxy-isobenzofuran-1,3-dione;METHYL N-(DIPHENYLMETHYLENE)-L-SERINATE;1,3-Isobenzofurandione, 5-methoxy-;5-Methoxy-2-benzofuran-1,3-dione;5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione
• CAS NO: 28281-76-7
• Molecular Formula: C₉H₆O₄
• Molecular Weight: 178.14154
• Mol File: 28281-76-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 98-99 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 348.574 °C at 760 mmHg
• Flash Point: 158.837 °C
• Appearance: /
• Density: 1.407 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-Methoxy-isobenzofuran-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-isobenzofuran-1,3-dione(28281-76-7)
• EPA Substance Registry System: 5-Methoxy-isobenzofuran-1,3-dione(28281-76-7)

Safety Data

• Hazardous Substances Data: 28281-76-7(Hazardous Substances Data)

Usage

Uses

5-Methoxyisobenzofuran-1,3-dione is used as a reagent in the synthesis of basic ethers of 1,2-dihydropyrrolo[1,2-α]indole, 6H-isoindolo[2,1-α]indole, and 6H-benz[5,6]isoindolo[2,1-α]indole which display antiproliferative activity.

Upstream product

• 794-94-5 p-Methoxybenzoic anhydride 
• 4741-63-3 6-methoxyphthalide 
• 3168-59-0 5-methoxy-o-toluic acid 
• 86-90-8 4-bromophthalic anhydride 
• 73502-03-1 methyl 5-methoxy-2-methyl-benzoate 
• 5368-81-0 methyl 3-methoxybenzoate 
• 1885-13-8 4-methoxyphthalic acid 
• 186581-53-3 diazomethane 
• 27550-59-0 4-hydroxyphthalic anhydride 
• 22895-19-8 dimethyl 4-methoxyphtalate 
• 22479-95-4 dimethyl 4-hydroxyphthalate 
• 85-44-9 phthalic anhydride 
• 610-35-5 4-hydroxyphthalic acid 
• 134-08-7 4-sulpho-phthalic anhydride 

Downstream Products

• 112045-54-2 5-methoxy-2-[2-(3-methyl-thiazolidin-2-yliden)-1-(4-oxo-3-phenyl-2-thioxo-thiazolidin-5-yliden)-ethyl]-benzoic acid 
• 108838-47-7 4-Methoxy-2-(3-methoxybenzoyl)benzoic acid 
• 76250-90-3 2-(3-Methoxybenzoyl)-5-methoxybenzoic Acid 
• 2158-93-2 2-benzoyl-4-methoxybenzoic acid 
• 2159-48-0 2-benzoyl-5-mnethoxybenzoic acid 
• 108837-28-1 4-methoxy-2-(4-methoxy-benzoyl)-benzoic acid 
• 108837-29-2 5-methoxy-2-(4-methoxybenzoyl)-benzoic acid 
• 28692-27-5 5-methoxy-isoindoline-1,3-dione-1,3-diimine 
• 62064-28-2 4-methoxy-2-[1]naphthoyl-benzoic acid 
• 2158-92-1 carboxy-2 methyl-5 benzophenone 
• 1147-41-7 4-methylbenzophenone-2-carboxylic acid 
• 10002-43-4 2-benzothiazol-2-yl-5-methoxy-benzoic acid 
• 10002-42-3 2-benzothiazol-2-yl-4-methoxy-benzoic acid 
• 19725-79-2 2-(2-Diazo-acetyl)-5-methoxy-benzoic acid methyl ester 

Relevant articles and documents

METHOD FOR SYNTHESIS OF LOBARIC ACID AND ANALOG THEREOF

The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.

NOVEL BROMINATED FURANONE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable 5 salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, 10 for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like.

Synthesis and biological evaluation of novel benzimidazole derivatives and analogs targeting the NLRP3 inflammasome

A series of benzo[d]imidazole analogues of thiabenzole were synthesized and their anti-inflammatory activities toward NLRP3 (nucleotide-binding domain leucine-rich repeat containing protein family, pyrin domain-containing 3, also known as cryopyrin or NALP3) inflammasome were evaluated in vitro. Two lead compounds, TBZ-09 and TBZ-21, were identified by anti-production of IL-1β. In the second round of biological evaluation, based on the lead, 34 more compounds were synthesized and their in vitro anti-inflammatory activities were investigated. Several compounds were identified as anti-inflammatory agents that can reduce IL-1β expression in a dose-dependent manner. A preliminary structure-activity relationship is also summarized here.