1885-13-8

Basic information

• Product Name: 4-Methoxyphthalic acid
• Synonyms: RARECHEM AL BO 1743;4-METHOXYPHTHALIC ACID;AKOS 212-42;4-METHOXYPHTALIC ACID;4-METHOXYPHTHALIC ACID,98+%;4-Methoxybenzene-1,2-dicarboxylic acid;Phthalic acid, 4-methoxy-
• CAS NO: 1885-13-8
• Molecular Formula: C₉H₈O₅
• Molecular Weight: 196.16
• EINECS: 217-546-2
• Mol File: 1885-13-8.mol
• Article Data: 25

Chemical Properties

• Melting Point: 178 °C(Solv: water (7732-18-5))
• Boiling Point: 394.036 °C at 760 mmHg
• Flash Point: 162.894 °C
• Appearance: /
• Density: 1.416 g/cm³
• Vapor Pressure: 6.46E-07mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: almost transparency in Methanol
• PKA: 3.13±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxyphthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxyphthalic acid(1885-13-8)
• EPA Substance Registry System: 4-Methoxyphthalic acid(1885-13-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 1885-13-8(Hazardous Substances Data)

Usage

General Description

4-Methoxyphthalic acid is a chemical compound with the molecular formula C9H8O5. It is a white crystalline powder that is soluble in water and organic solvents. 4-Methoxyphthalic acid is often used in the production of dyes and pigments, as well as in the synthesis of pharmaceuticals and other organic compounds. It is also used as a building block in the creation of polymers and resins. 4-Methoxyphthalic acid has been found to have potential antimicrobial and antioxidant properties, making it valuable in the development of various industrial and consumer products. Additionally, it is considered to have low toxicity and is generally regarded as safe for use in the intended applications.

InChI:InChI=1/C9H8O5/c1-14-5-2-3-6(8(10)11)7(4-5)9(12)13/h2-4H,1H3,(H,10,11)(H,12,13)

Upstream product

• 4685-47-6 3,4-dimethylanisole 
• 67-56-1 methanol 
• 86-90-8 4-bromophthalic anhydride 
• 124-41-4 sodium methylate 
• 22479-95-4 dimethyl 4-hydroxyphthalate 
• 74-88-4 methyl iodide 
• 201230-82-2 carbon monoxide 
• 586-38-9 3-Methoxybenzoic acid 
• 610-35-5 4-hydroxyphthalic acid 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 20734-74-1 5-methoxy-2-methyl-phenol 
• 7577-76-6 4-acetoxy-4-methyl-2,5-cyclohexanedienone 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 50727-04-3 4-methoxyphthalimide 
• 522-53-2 lobaric acid 
• 1372167-27-5 lobarin 
• 1233145-41-9 6-methoxy-2-methylisoindolin-5-amine 
• 630407-39-5 5-methoxy-2-methylisoindoline 
• 21794-55-8 (+)-Daunomycinone 
• 92498-02-7 5-methoxy-2-phenylisoindoline-1,3-dione 
• 60889-21-6 6-methoxyphthalazin-1-(2H)-one 
• 4741-62-2 5-methoxyisobenzofuran-1(3H)-one 
• 65399-12-4 2-hydroxymethyl-4-methoxy-benzoic acid 

Relevant articles and documents

NOVEL BROMINATED FURANONE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable 5 salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, 10 for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like.

Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor–Acceptor Cyclopropanes

Efficient methods for the convergent synthesis of (poly)cyclic scaffolds are urgently needed in synthetic and medicinal chemistry. Herein, we describe new annulation reactions of thioalkynes with phthalimide-substituted donor–acceptor cyclopropanes, which gave access to highly substituted cyclopentenes and polycyclic ring systems. With silyl-thioalkynes, the Lewis acid catalyzed [3+2] annulation reaction with donor–acceptor cyclopropanes took place to afford 1-thio-cyclopenten-3-amines. On the other hand, an unprecedented polycyclic compound was formed with alkyl-thioalkynes through a reaction pathway directly involving the phthalimide group. The two transformations proceeded in good yields and tolerated a large variety of functional groups.