28285-98-5

Upstream product

• 117-34-0 2,2-diphenylacetic acid 
• 1871-76-7 diphenylacetic acid chloride 
• 41993-27-5 2,2-diphenyl-1-p-tolylethanone 

Downstream Products

• 4625-47-2 1-hydroxy-1,1-diphenyl-2-(4-methylphenyl)ethan-2-one 

Relevant academic research and scientific papers

Method for preparation of 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone

The invention relates to a method for preparation of 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone, wherein the method includes the steps: a), carrying out a reaction of 2,2-diphenyl acetic acid with phosphorus trichloride to prepare 2,2-diphenyl acetyl chloride; b), carrying out a reaction of 2,2-diphenyl acetyl chloride with toluene to prepare 2,2-diphenyl-1-(p-methylphenyl)ethanone; c), carrying out a reaction of 2,2-diphenyl-1-(p-methylphenyl)ethanone with bromine to prepare 2-bromo-2,2-diphenyl-1-(p-methylphenyl)ethanone; and d), carrying out a reaction of 2-bromo-2,2-diphenyl-1-(p-methylphenyl)ethanone with an alkali liquid to prepare 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone. The method has simple synthesis process, greatly reduces the dangerousness of the reactions, reduces the pollution to the environment, and is favorable for amplified and industrialized production.