4625-47-2

Upstream product

• 41993-27-5 2,2-diphenyl-1-p-tolylethanone 
• 119-61-9 benzophenone 
• 2942-54-3 diethyl (4-methylbenzoyl)phosphonate 
• 104-85-8 para-methylbenzonitrile 
• 2431-00-7 p-methylbenzil 
• 934-56-5 trimethyl(phenyl)stannane 
• 117-34-0 2,2-diphenylacetic acid 
• 1871-76-7 diphenylacetic acid chloride 
• 28285-98-5 2-bromo-2,2-diphenyl-1-(p-tolyl)ethanone 

Relevant academic research and scientific papers

Method for preparation of 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone

The invention relates to a method for preparation of 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone, wherein the method includes the steps: a), carrying out a reaction of 2,2-diphenyl acetic acid with phosphorus trichloride to prepare 2,2-diphenyl acetyl chloride; b), carrying out a reaction of 2,2-diphenyl acetyl chloride with toluene to prepare 2,2-diphenyl-1-(p-methylphenyl)ethanone; c), carrying out a reaction of 2,2-diphenyl-1-(p-methylphenyl)ethanone with bromine to prepare 2-bromo-2,2-diphenyl-1-(p-methylphenyl)ethanone; and d), carrying out a reaction of 2-bromo-2,2-diphenyl-1-(p-methylphenyl)ethanone with an alkali liquid to prepare 2-hydroxy-2,2-diphenyl-1-(p-methylphenyl)ethanone. The method has simple synthesis process, greatly reduces the dangerousness of the reactions, reduces the pollution to the environment, and is favorable for amplified and industrialized production.

A novel lanthanum metal-assisted reaction of diaryl ketones and electrophiles

A novel and efficient lanthanum metal-assisted carbon-carbon bond formation of diaryl ketones and various electrophiles, such as carbonyl compounds, esters, nitriles, and epoxides, has been developed. When diaryl ketones were allowed to react with dialkyl ketones in the presence of lanthanum metal and a catalytic amount of iodine, the cross pinacol coupling reaction proceeded to give the corresponding unsymmetrical 1,2-diols in moderate to good yields. α-Hydroxy ketones were prepared by the lanthanum metal-assisted reaction of diaryl ketones with esters or nitriles, followed by hydrolysis with aq HCl. It is interesting to note that for the epoxides, the coupling reaction proceeded via the Meinwald rearrangement of epoxides to give the corresponding 1,2-diols.

Rhodium-catalyzed addition of arylstannanes to carbon-heteroatom double bond

The addition of arylstannanes to the carbon-heteroatom double bond in the presence of a catalytic amount of a cationic rhodium complex ([Rh(cod)(MeCN)2]BF4) was examined. The reactions of aldehydes, α-dicarbonyl compounds, and N-substituted aldimines with the arylstannanes gave corresponding alcohols, α-hydroxy carbonyl compounds, and amines, respectively. An arylrhodium complex generated by the transmetalation with the arylstannane was probably the active catalytic species.

Regioselective superacid-catalyzed electrocyclization of diphenylmethyl cations to fluorenes, phenanthrols and benzofurans

Cationic electrocyclization of α-benzoyldiphenylmethanols in the presence of superacid provides fluorenes, phenanthrols and benzofurans in good to moderate yields. A single substitution leads to regioselective cationic electrocyclizations.

Samarium(II) iodide-promoted intermolecular and intramolecular ketone- nitrile reductive coupling reactions

Samarium (II) iodide, a strong one-electron transfer reducing reagent, has been successfully utilized for the intermolecular and intramolecular reductive coupling reactions of ketones with nitriles, α-Hydroxy ketones, monocyclic, fused bicyclic α-hydroxy ketones and monocyclic α-amino alcohols composed of a number of substitution patterns have been prepared in good yields at room temperature or reflux under neutral conditions. The procedure can avoid overreduction of the resulting of α-hydroxy ketones or α-amino alcohols. The crystal structures of monocyclic α-amino alcohols are reported.

Three-Component Coupling of Acylphosphonates and Two Carbonyl Compounds Promoted by Low-Valent Samariums: One-Pot Synthesis of β-Hydroxyphosphonates

Three-component coupling of acylphosphonates and two carbonyl compounds leading to β-hydroxyphosphonates has been achieved with low-valent samariums. Thus, acylphosphonates reacted with aldehydes in the presence of semicatalytic amounts of samarium metal or SmI2 to give acyloxyphosphonates in good yields. The second coupling reaction of the acyloxyphosphonates with aldehydes or ketones promoted by SmI2 afforded β-hydroxyphosphonates instead of olefins. Moreover, these two reactions could be carried out in one pot.