28317-50-2

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 95-76-1 m,p-dichloroaniline 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 1000576-77-1 ethyl 1-(3,4-dichlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-carboxylate 
• 92126-23-3 1-(3,4-dichlorophenyl)-5-methyl-3,4-bis(hydroxymethyl)pyrazole bis(methylcarbamate) 
• 92126-20-0 1-(3,4-dichlorophenyl)-5-methyl-3,4-bis(hydroxymethyl)pyrazole 
• 92126-18-6 diethyl 1-(3,4-dichlorophenyl)-5-methylpyrazole-3,4-dicarboxylate 

Relevant academic research and scientific papers

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid–leucine–arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block

A new method for the synthesis of 1-aryl-1,2,4-triazole derivatives

A new and convenient one-step recyclization method for the synthesis of ethyl 1-aryl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-carboxylates is reported. Various ethyl chloro(2-arylhydrazinylidene)ethanoates react with thiazolidine-2,4-dione in the presence of potassium hydroxide to produce the 1-aryl-1,2,4-triazole derivatives in moderate to good yields. The procedure is economical, environmentally friendly and simple to perform. Georg Thieme Verlag Stuttgart - New York.

Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents

A series of bis(hydroxymethyl)-substituted heterocycles were synthesized and converted to the corresponding bis(methylcarbamate) derivatives. The heterocyclic systems studied were based on 2-phenyl-3-methylfuran, 1-phenylpyrazole, 1-phenyl-5-methylpyrazole, 1-phenyl-5-methylthiopene, 1-phenyl-1,2,3-triazole, 3-phenylisoxazole, 3-phenylisothiazole, 2-phenylthiazole, and 2-phenyloxazole. None of the bis(carbamates) prepared was active against murine P388 lymphocytic leukemia. Pyrrole bis(carbamate), which exhibited antileukemic activity, also showed reactivity toward 4-(p-nitrobenzyl)pyridine while the inactive bis(carbamates) were unreactive in the 4-(p-nitrobenzyl)pyridine assay.