283173-70-6Relevant academic research and scientific papers
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis, and X-ray cocrystal structure
Canan Koch, Stacie S.,Thoresen, Lars H.,Tikhe, Jayashree G.,Maegley, Karen A.,Almassy, Robert J.,Li, Jianke,Yu, Xiao-Hong,Zook, Scott E.,Kumpf, Robert A.,Zhang, Cathy,Boritzki, Theodore J.,Mansour, Rena N.,Zhang, Kanyin E.,Ekker, Anne,Calabrese, Chris R.,Curtin, Nicola J.,Kyle, Suzanne,Thomas, Huw D.,Wang, Lan-Zhen,Calvert, A. Hilary,Golding, Bernard T.,Griffin, Roger J.,Newell, David R.,Webber, Stephen E.,Hostomsky, Zdenek
, p. 4961 - 4974 (2002)
A series of novel compounds have been designed that are potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1), and the activity and physical properties have been characterized. The new structural classes, 3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol
