53462-75-2

Usage

InChI:InChI=1/C10H8N2O/c13-10-7-2-1-3-8-9(7)6(4-11-8)5-12-10/h1-4,11H,5H2,(H,12,13)

Upstream product

• 851659-71-7 4-methylidene-5-nitro-3,4-dihydro-2H-isoquinolin-1-one 
• 851659-70-6 2-bromo-3-nitro-N-(2-propen-1-yl)benzamide 
• 6286-36-8 2-bromo-3-nitrobenzoic acid chloride 
• 573-54-6 2-bromo-3-nitro-benzoic acid 
• 57280-91-8 3-(Aminomethyl)indole-4-carboxylic Acid Methyl Ester 
• 93-61-8 N-methyl-N-phenylformamide 
• 53462-88-7 3-Formylindole-4-carboxylic acid methyl ester 

Downstream Products

• 1059131-08-6 1-(phenylsulfonyl)-3,4-dihydropyrrolo[4,3,2-de]isoquinolin-5(1H)-one 
• 53269-34-4 1,3,4,5-tetrahydro-pyrrolo[4,3,2-de]isoquinoline 
• 1059128-86-7 1-(phenylsulfonyl)-1,3,4,5-tetrahydropyrrolo[4,3,2-de]isoquinoline 
• 1059128-87-8 4-methyl-1-(phenylsulfonyl)-1,3,4,5-tetrahydropyrrolo[4,3,2-de]isoquinoline 
• 1059129-07-5 1-[(2-chlorophenyl)sulfonyl]-4-ethyl-1,3,4,5-tetrahydropyrrolo[4,3,2-de]isoquinoline 
• 1059128-98-1 4-ethyl-1-(phenylsulfonyl)-1,3,4,5-tetrahydropyrrolo[4,3,2-de]isoquinoline trifluoroacetate 
• 283173-70-6 4-formylphenyl-3,4-dihydropyrrolo[4,3,2-de]isoquinolin-5-(1H)-one 
• 478943-31-6 3-formylphenyl-3,4-dihydropyrrolo[4,3,2-de]isoquinolin-5-(1H)-one 

Relevant academic research and scientific papers

TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY

The present invention relates to novel compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their

Synthesis of fused indoles by sequential palladium-catalyzed Heck reaction and N-heteroannulation

A route to 3,4-fused indoles via two consecutive palladium-catalyzed reactions; an intramolecular Heck reaction followed by a reductive N-heteroannulation is described. Using this route, a number of indoles have been prepared having a variety of ring sizes anchored to the 3- and 4-position of the indole nucleus. Furthermore, a number of functional groups, both carbon and heteroatom substituents can be introduced in (and on) the additional ring without any detrimental effects on the two reactions.

Pyrroloisoquinoline derivatives

1,3,4,5-Tetrahydropyrrolo[4,3,2-de]isoquinoline and its N-alkyl derivatives are disclosed. The compounds are antidepressant and antihypertensive agents. Methods for their preparation and use are disclosed.

Certain 4,6-dihydropyrrolotriazoline-quinoline derivatives

1,3-Dihydropyrrolo[4,3,2-de]isoquinoline derivatives characterized by an amino or hydrazino substituent at position 5 are disclosed. Also included are the related 4,6-dihydropyrrolo[4,3,2-de]-s-triazolo[3,4-a]isoquinoline and its 8-methyl derivative. The compounds are antidepressant and antihypertensive agents. Methods for their preparation and use are disclosed.