2834-79-9Relevant articles and documents
Synthesis, X-ray crystallographic, spectroscopic and computational studies of aminothiazole derivatives
Adeel, Muhammad,Braga, Ataualpa A.C.,Tahir, Muhammad Nawaz,Haq, Fazal,Khalid, Muhammad,Halim, Mohammad A.
, p. 136 - 148 (2017)
Aminothiazole organic compounds have diverse biological applications. Herein we report the synthesis of two aminothiazole derivatives: 4-(biphenyl-4-yl)thiazol-2-amine (1) and 4-(2′,4′-difluorobiphenyl-4-yl)thiazol-2-amine (2) via Suzuki-Miyaura cross cou
SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES
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Page/Page column 14; 42, (2019/11/12)
The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation
Ramesh, Gondru,Janardhan, Banothu,Rajitha, Bavantula
, p. 8099 - 8109 (2015/04/16)
An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10-60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.