5707-44-8Relevant articles and documents
Copper-Catalyzed and Proton-Directed Selective Hydroxymethylation of Alkynes with CO2
Wang, Mei-Yan,Jin, Xin,Wang, Xiaofei,Xia, Shumei,Wang, Yue,Huang, Shouying,Li, Ying,He, Liang-Nian,Ma, Xinbin
supporting information, p. 3984 - 3988 (2020/12/25)
An intriguing strategy for copper-catalyzed hydroxymethylation of alkynes with CO2 and hydrosilane was developed. Switched on/off a proton source, for example, tBuOH, direct hydroxymethylation and reductive hydroxymethylation could be triggered selectively, delivering a series of allylic alcohols and homobenzylic alcohols, respectively, with high levels of Z/E, regio- and enantioselectivity. Such a selective synthesis is attributed to the differences in response of vinylcopper intermediate to proton and CO2. The protonation of vinylcopper species is demonstrated to be prior to hydroxymethylation, thus allowing a diversion from direct alkyne hydroxymethylation to reductive hydroxymethylation in the presence of suitable proton.
Pd-PEPPSI complexes based on 1,2,4-triazol-3-ylidene ligands as efficient catalysts in the Suzuki—Miyaura reaction
Chernenko, A. Yu.,Astakhov,Pasyukov,Dorovatovskii,Zubavichus, Ya. V.,Khrustalev,Chernyshev
, p. 79 - 84 (2018/04/27)
The palladium complexes of the Pd-PEPPSI type with N-heterocyclic carbenes of the 1,2,4-triazole series were synthesized in 76—99% yields by the reactions of PdCl2 with 1,4-di- alkyl-1,2,4-triazolium salts in pyridine in the presence of KBr or KI as sources of halide ions and tetrabutylammonium salts as phase-transfer catalysts. The obtained complexes can be used as efficient catalysts for the Suzuki—Miyaura cross-coupling and are not inferior to the commercially available Pd-PEPPSI catalysts in activity.
Amide-ligand-controlled highly para-selective arylation of monosubstituted simple arenes with arylboronic acids
Luan, Yu-Xin,Zhang, Tao,Yao, Wei-Wei,Lu, Ke,Kong, Lu-Yao,Lin, Yu-Tong,Ye, Mengchun
supporting information, p. 1786 - 1789 (2017/02/15)
Pd-catalyzed highly para-selective arylations of monosubstituted simple arenes with arylboronic acids to widely existed biaryls have been developed. Inspired by requisite amide-directing groups in reported selective oxidative couplings, amide ligands, especially DMF, are designed and found to be critical for the selectivity control in current arylations.
