28341-73-3

Basic information

• Product Name: Imidazolidine, 1,2,3-triphenyl-
• Synonyms: 1,2,3-triphenyl-imidazolidine;1,2,3-Triphenyltetrahydroimidazol;1,2,3-Triphenyl-imidazolidin;1,2,3-Triphenylimidazolidin
• CAS NO: 28341-73-3
• Molecular Formula: C21H20N2
• Molecular Weight: 300.403
• Mol File: 28341-73-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Imidazolidine, 1,2,3-triphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazolidine, 1,2,3-triphenyl-(28341-73-3)
• EPA Substance Registry System: Imidazolidine, 1,2,3-triphenyl-(28341-73-3)

Safety Data

• Hazardous Substances Data: 28341-73-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 150-61-8 N,N'-diphenylethylenediamine 
• 62-53-3 aniline 
• 1484-17-9 S-ethyl thiobenzoate 
• 100-47-0 benzonitrile 

Downstream Products

• 6200-83-5 N-Benzoyl-1,2-dianilinoethan 

Relevant articles and documents

Synthesis and evaluation of antiinflammatory and analgesic activity of some new 1,3-diphenyl-2-aryltetrahydroimidazoles

In an effort to search for new antiinflammatory and analgesic agents, some new tetrahydroimidazole derivatives 2a-2g have been synthesized via condensation of 1,2-dianilinoethane with various aldehydes. Characterization of the newly synthesized compounds has been done on the basis of 1H NMR and mass spectral data. The resulting compounds have been evaluated for their antiinflammatory activity. The activity of compounds 2b and 2c is excellent and comparable to indomethacin. All these compounds have been tested for their analgesic activity also and their LD50 determined. Compounds 2b and 2c show a comparable activity with aspirin. The MTD for all the compounds is found to be >1800 mg/kg.

BENTONITE K10 CLAY, AN EFFICIENT CATALYST FOR THE FORMATION OF NITROGEN DERIVATIVES

Bentonite K10 clay has been used to catalyze the formation of enamino carbonyl derivatives, 2-methyl-1H-benzimidazoles, Hantzsch 1,4-dihydropyridines, Hantzsch pyridines, 2-substituted 1,3-diphenylimidazolidines, and tetrahydropyranylbenzazoles.

Reduction of Substituted 1H-4,5-Dihydroimidazolium Salts

Reactions of several substituted 1H-4,5-dihydroimidazolium salts 1 with nucleophilic and electrophilic reducing agents acting via hydride transfer were explored.Reaction of compounds 1 with lithium aluminum hydride in THF afforded the corresponding imidazolidines 2.When alkaline borohydrides (sodium borohydride, potassium borohydride, sodium cyanoborohydride) in ethanol at room temperature were used, partial or total over-reduction of compounds 2 leading to N,N,N'-trisubstituted ethylenediamines took place on occasion.Results may be explained taking into account that reductive cleavage of 2 proceeds via a stabilized iminium ion present in protic solvents.Treatment of compounds 1 with an excess of borane in THF afforded the corresponding imidazolidines 2 or their borane complexes, according to the substituent type.