28341-73-3

Upstream product

• 100-52-7 benzaldehyde 
• 150-61-8 N,N'-diphenylethylenediamine 
• 100-47-0 benzonitrile 
• 62-53-3 aniline 
• 1484-17-9 S-ethyl thiobenzoate 

Downstream Products

• 6200-83-5 N-Benzoyl-1,2-dianilinoethan 

Relevant academic research and scientific papers

Synthesis and evaluation of antiinflammatory and analgesic activity of some new 1,3-diphenyl-2-aryltetrahydroimidazoles

In an effort to search for new antiinflammatory and analgesic agents, some new tetrahydroimidazole derivatives 2a-2g have been synthesized via condensation of 1,2-dianilinoethane with various aldehydes. Characterization of the newly synthesized compounds has been done on the basis of 1H NMR and mass spectral data. The resulting compounds have been evaluated for their antiinflammatory activity. The activity of compounds 2b and 2c is excellent and comparable to indomethacin. All these compounds have been tested for their analgesic activity also and their LD50 determined. Compounds 2b and 2c show a comparable activity with aspirin. The MTD for all the compounds is found to be >1800 mg/kg.

Synthesis of substituted 1H-4,5-dihydroimidazolium salts by dehydrogenation of imidazolidines

A study is presented on the scope of the method to obtain 1H-4,5-dihydroimidazolium salts 3 by dehydrogenation of 1,3-di and 1,2,3-trisubstituted imidazolidines 2. Of the dehydrogenating agents used, N-bromoacetamide leads to the best results, providing a

BENTONITE K10 CLAY, AN EFFICIENT CATALYST FOR THE FORMATION OF NITROGEN DERIVATIVES

Bentonite K10 clay has been used to catalyze the formation of enamino carbonyl derivatives, 2-methyl-1H-benzimidazoles, Hantzsch 1,4-dihydropyridines, Hantzsch pyridines, 2-substituted 1,3-diphenylimidazolidines, and tetrahydropyranylbenzazoles.

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, a Mild Catalyst for the Formation of Carbon-Nitrogen Bonds

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) catalyzes the preparation of N-tetrahydropyranylbenzazoles, 2-substituted 1,3-diphenylimidazolidines, and N-(arylmethylene)benzene-1,2-diamines.In the latter case, use of one equivalent of DDQ provides a novel one-pot method for the synthesis of 1H-benzimidazoles.

Reduction of Substituted 1H-4,5-Dihydroimidazolium Salts

Reactions of several substituted 1H-4,5-dihydroimidazolium salts 1 with nucleophilic and electrophilic reducing agents acting via hydride transfer were explored.Reaction of compounds 1 with lithium aluminum hydride in THF afforded the corresponding imidazolidines 2.When alkaline borohydrides (sodium borohydride, potassium borohydride, sodium cyanoborohydride) in ethanol at room temperature were used, partial or total over-reduction of compounds 2 leading to N,N,N'-trisubstituted ethylenediamines took place on occasion.Results may be explained taking into account that reductive cleavage of 2 proceeds via a stabilized iminium ion present in protic solvents.Treatment of compounds 1 with an excess of borane in THF afforded the corresponding imidazolidines 2 or their borane complexes, according to the substituent type.

NOVEL SYNTHESES OF HETEROCYCLES WITH N-(1-HALOALKYL)AZINIUM HALIDES PART 1. PREPARATION OF IMIDAZOLIDINES

N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and an aldehyde, readily react with N,N'-disubstituted 1,2-ethanediamine to yield imidazolidines under mild and neutral conditions.