28353-92-6

Upstream product

• 100-84-5 1-methoxy-3-methyl-benzene 
• 28353-89-1 β-(4-methoxy-2-methylphenyl)-propionitrile 
• 18158-46-8 3-(4-methoxy-2-methylphenyl)prop-2-enoic acid 
• 103203-88-9 2-methyl-4-hydroxycinnamic acid 

Downstream Products

• 105731-18-8 methyl 3-(4-hydroxy-2-methylphenyl)propanoate 
• 122054-06-2 3-(4-acetoxy-2-methylphenyl)propionic acid 
• 129667-21-6 3-{3-[5-(2-Carboxy-ethyl)-2-hydroxy-4-methyl-phenyl]-3,6-dimethyl-2-oxo-2,3-dihydro-benzofuran-5-yl}-propionic acid 
• 129667-20-5 2,3-dihydro-3,6-methyl-2-oxo-3-(phenylthio)benzofuran-5-propanoic acid 
• 137645-15-9 benzyl 3-(4-hydroxy-2-methylphenyl)propionate 
• 122054-07-3 1-(4-acetoxy-2-methylphenyl)-4-diazopentan-3-one 
• 137645-16-0 benzyl 3-(4-phenylacetoxy-2-methylphenyl)propionate 
• 137644-80-5 2-diazo-5-(2-methyl-4-phenylacetoxyphenyl)pentan-3-one 
• 137645-19-3 Phenyl-acetic acid 3a,7-dimethyl-3-oxo-2,3,3a,3b-tetrahydro-1H-cyclopenta[1,3]cyclopropa[1,2]benzen-5-yl ester 
• 137644-79-2 3-(2-methyl-4-phenylacetoxyphenyl)propionic acid 

Relevant academic research and scientific papers

Organic Synthesis with α-Chloro Sulphides. Preparation of Aromatic γ-Lactones from Phenols and α-Chloro Sulphide Carboxylates

Lewis acid-catalysed alkylation of para-substituted phenols using α-chloro sulphides as electrophiles yields sulphenylated γ-lactones which can be desulphurised with zinc in acetic acid or Raney nickel.This synthesis has been applied to p-cresol, 2-naphthol, and two phenolic dihydrocinnamates.Alkylation of 1,4-dimethoxybenzene yields homogentisic acid dimethyl ether after desulphurisation and hydrolysis.

Synthesis of 4-Hydroxy-2-methylbenzoic Acid and Its Higher Homologues

Synthesis of 4-hydroxy-2-methylbenzoic acid (1a) and its higher homologues such as 4-hydroxy-2-methylphenylacetic acid (1b), 3-(4-hydroxy-2-methylphenyl)propanoic acid (1c) and 4-(4-hydroxy-2-methylphenyl)butanoic acid (1d) are described.