122054-07-3Relevant academic research and scientific papers
A New Route to Functionalised Hydroazulenes. Synthesis of (/-)-Confertin
Kennedy, Michael,McKervey, M. Anthony
, p. 1028 - 1030 (1988)
The advenced confertin intermediate (13) has been synthesized in 20percent yield from a simple dihydrocinnamic acid precursors, the hydroazulene skeleton having been constructed by rhodium(II) mandelate-catalysed cyclisationring expansion of an α-diazoketone.
Pseudoguaianolides from Intramolecular Cycloadditions of Aryl Diazoketones: Synthesis of (+/-)-Confertin and an Approach to the Synthesis of (+/-)-Damsin
Kennedy, Michael,McKervey, M. Anthony
, p. 2565 - 2574 (2007/10/02)
Rhodium(II) mandelate-catalysed cyclisation of α-diazoketones derived from 3-arylpropionic acids produces bicyclodecatrienones, one of which has been used to synthesise an advanced (+/-)-confertin intermediate in six stages and 20percent overall yield.The possibility of constructing intermediates for the synthesis of damsin-like pseudoguaianolides via catalysed diazoketone cyclisation is also examined and methods for the construction of polyfunctional 3-arylpropionic acids suitable for use as damsin precursors are presented.
