28357-95-1Relevant academic research and scientific papers
TETRAPEPTIDE INHIBITORS OF BETA-SECRETASE
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Page/Page column 11; 26, (2008/06/13)
Statine-derived peptide inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful meth
N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
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, (2008/06/13)
N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids of formula I STR1 wherein R is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic or heteroarylaliphatic radical having at least 2 carbon atoms, R1 is hydrogen or hydroxy, R2 is an araliphatic or heteroarylaliphatic radical substituted by free or functionally modified carboxy that is bonded directly or by way of a spacer, and R3 is hydrogen, lower alkyl or a group R2, and the salts thereof have valuable nootropic and anti-epileptic properties and can be used in the preparation of a nootropic or anti-epileptic medicament.
Benzoic acid and benzoic acid ester derivatives to treat headaches
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, (2008/06/13)
Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpe
