2836-40-0

Basic information

• Product Name: 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide
• Synonyms: 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide;2,4'-Dichloro-2'-(2-fluorobenzoyl)acetoanilide
• CAS NO: 2836-40-0
• Molecular Formula: C₁₅H₁₀Cl₂FNO₂
• Molecular Weight: 326.1498032
• EINECS: 220-625-4
• Mol File: 2836-40-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 565.7 °C at 760 mmHg
• Flash Point: 296 °C
• Appearance: /
• Density: 1.429 g/cm³
• Vapor Pressure: 8.07E-13mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide(2836-40-0)
• EPA Substance Registry System: 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide(2836-40-0)

Safety Data

• Hazardous Substances Data: 2836-40-0(Hazardous Substances Data)

Usage

General Description

2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide is a chemical compound with the molecular formula C15H11Cl2FNO2. It is an acetamide derivative with two chlorine atoms and one fluorobenzoyl group attached to the phenyl ring. 2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide is commonly used in the pharmaceutical industry as a building block in the synthesis of various drugs and pharmaceutical intermediates. It has also been studied for its potential biological activities, including its anti-inflammatory and analgesic properties. The presence of the chloro and fluorobenzoyl groups in its structure suggests that it may have interactions with biological targets such as enzymes or receptors, making it a potentially useful molecule in drug development and medicinal chemistry.

InChI:InChI=1/C15H10Cl2FNO2/c16-8-14(20)19-13-6-5-9(17)7-11(13)15(21)10-3-1-2-4-12(10)18/h1-7H,8H2,(H,19,20)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 

Downstream Products

• 2147-80-0 3,3'-bis-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-1,1'-methanediyl-bis-imidazolidin-4-one 
• 2886-65-9 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one 
• 2147-81-1 3-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-imidazolidin-4-one 
• 880875-76-3 C₂₀H₁₃ClFN₂O⁽¹⁺⁾*Cl^(1-) 
• 1645-32-5 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-thione 

Relevant articles and documents

Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives

A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC50 of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively).