283603-57-6Relevant articles and documents
Hydride-Mediated Homogeneous Catalysis. Catalytic Reduction of α,β-Unsaturated Ketones Using 6 and H2
Mahoney, Wayne S.,Stryker, Jeffrey M.
, p. 8818 - 8823 (2007/10/02)
Hydride-mediated reduction of α,β-unsaturated ketones catalytic in the hydride reagent is reported using 6 and molecular hydrogen.The reaction proceeds at room temperature and is highly regioselective, affording either the product of conjugate reduction or complete 1,4- and 1,2-reduction to the saturated alcohol, depending on reaction conditions.In the presence of excess phosphine, the process is homogeneous and chemoselective: isolated double bonds are not hydrogenated, even under forcing conditions.This novel catalytic reduction appears to proceed viathe heterolytic activation of molecular hydrogen by highly reactive copper(I) enolate and alkoxide intermediates.
