283610-05-9

Upstream product

• 503822-33-1 (R)-2-(allylamino)-2-phenylethanol 
• 56613-80-0 D-2-phenylglycinol 
• 870138-26-4 (2R,4R)-3-allyl-2-isopropyl-4-phenyloxazolidine 

Downstream Products

• 41720-99-4 (S)-(-)-2-(1-methylethyl)-pyrrolidine 

Relevant academic research and scientific papers

Stereoselective synthesis of pyrrolidines from N-allyl oxazolidines via hydrozirconation-cyclization

(Chemical Equation Presented) A new diastereoselective synthesis of pyrrolidines from readily available chiral N-allyl oxazolidines is presented. The construction of the pyrrolidine ring is achieved via a tandem hydrozirconation-stereoselective Lewis acid

A simple stereoselective synthesis of enantiopure 2-substituted pyrrolidines and piperidines from chiral (R)-phenylglycinol-derived bicyclic 1,3-oxazolidines

Chiral, nonracemic 2-substituted pyrrolidines and piperidines were prepared in high ee and moderate to good chemical yields in three steps from (R)-phenylglycinol and γ- or δ-chloroketones. The key step of the synthesis was the stereo- selective reductive ring-opening of chiral bicyclic 1,3- oxazolidines prepared by condensation of (R)-phenylglycinol and the corresponding ketones.