41720-99-4

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-Isopropylpyrrolidine is used as a chiral auxiliary for the synthesis of pharmaceuticals, contributing to the development of enantiomerically pure drugs. Its ability to induce stereoselectivity in chemical reactions is crucial for producing drugs with desired therapeutic effects and minimizing side effects.
Used in Agrochemical Industry:
In the agrochemical sector, (2S)-2-Isopropylpyrrolidine serves as a chiral building block for the synthesis of agrochemicals. It aids in the production of enantiomerically pure active ingredients, ensuring targeted effects on pests and reducing potential environmental impact.
Used in Fine Chemicals Production:
(2S)-2-Isopropylpyrrolidine is utilized as a reagent in the synthesis of various fine chemicals, including those used in the fragrance and flavor industries. Its chiral properties allow for the creation of enantiomerically pure compounds that can impart specific scents or tastes to products.
Used in Material Science:
(2S)-2-ISOPROPYLPYRROLIDINE also shows promise in material science, where it may be employed in the development of new materials with unique properties. Its chiral nature could contribute to the creation of materials with specific structural and functional characteristics.
Overall, (2S)-2-Isopropylpyrrolidine is a versatile compound with applications spanning across multiple industries, primarily due to its role as a chiral building block and its potential in enhancing the stereochemical purity of synthesized products.

Upstream product

• 118970-92-6 (S)-(-)-1-benzyl-2-(1-hydroxy-1-methylethyl)-pyrrolidine 
• 615268-20-7 (4R)-N-benzyl-N-(tert-butyloxycarbonyl)-4-diphenylphosphatoxy-5-methyl-5-nitro-hexylamine 
• 615268-22-9 (4R)-N-benzyl-4-diphenylphosphatoxy-5-methyl-5-nitro-hexylamine 
• 615268-18-3 (4R)-N-benzyl-N-(tert-butyloxycarbonyl)-4-hydroxy-5-methyl-5-nitro-hexylamine 
• 477952-41-3 6-[N-benzyl-N-(tert-butyloxycarbonyl)]amino-2-methyl-2-nitro-2-hexanone 
• 477952-40-2 6-[N-benzyl-N-(tert-butyloxycarbonyl)]amino-3-hydroxy-2-methyl-2-nitrohexane 
• 615268-24-1 (S)-1-benzyl-2-isopropyl-pyrrolidine 
• 283610-05-9 (2R)-2-[(2'S)-2'-isopropyl-N-pyrrolidinyl]-2-phenyl-1-ethanol 

Downstream Products

• 123445-42-1 1-((S)-2-Isopropyl-pyrrolidin-1-yl)-propenone 

Relevant academic research and scientific papers

Enantioselective alkene radical cations reactions

The reaction of enantiomerically enriched 2-methyl-2-nitro-3-(diphenylphosphatoxy)alkyl radicals with tributyltin hydride and AIBN in benzene at reflux results in the formation of alkene radical cation/anion pairs, which are trapped intramolecularly by am

Enantioselective cyclization of alkene radical cations

(Matrix Presented) Enantiomerically enriched β-(diphenylphosphatoxy) nitroalkanes undergo radical ionic fragmentation, induced by tributyltin hydride and AIBN in benzene at reflux, to give alkene radical cations in contact radical ion pairs. These contact

A simple stereoselective synthesis of enantiopure 2-substituted pyrrolidines and piperidines from chiral (R)-phenylglycinol-derived bicyclic 1,3-oxazolidines

Chiral, nonracemic 2-substituted pyrrolidines and piperidines were prepared in high ee and moderate to good chemical yields in three steps from (R)-phenylglycinol and γ- or δ-chloroketones. The key step of the synthesis was the stereo- selective reductive ring-opening of chiral bicyclic 1,3- oxazolidines prepared by condensation of (R)-phenylglycinol and the corresponding ketones.

LARGE SCALE PREPARATION OF VERSATILE CHIRAL AUXILIARIES DERIVED FROM (S)-PROLINE

The synthesis of a variety of enantiomerically pure chiral auxiliaries based on (S)-proline and bearing sterically demanding side chains at the pyrrolidine moiety, such as the secondary amines (S)-3,5 and 7 and the hydrazines (S)-6, is described on a molar scale.As key step, the Grignard or RLi addition to the N-benzylated proline ester (S)-1 is used.