28362-76-7Relevant articles and documents
One-Pot Preparation of C1-Homologated Aliphatic Nitriles from Aldehydes through a Wittig Reaction under Metal-Cyanide-Free Conditions
Ezawa, Masatoshi,Togo, Hideo
, p. 2379 - 2384 (2017/05/01)
A one-pot protocol to obtain C1-homologated aliphatic nitriles was achieved by treating aromatic and aliphatic aldehydes with the (methoxymethyl)triphenylphosphonium ylide followed by hydrolysis of the resulting methyl vinyl ethers with pTsOH (Ts = para-toluenesulfonyl) and treatment with molecular iodine and aqueous ammonia under metal cyanide free conditions. Neopentyl-type nitriles, which could not be obtained by conventional methods that involved conversion of the neopentyl alcohol into a tosylate and treatment with metal cyanide, were successfully obtained by using the present method.
Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues
Gemma, Sandra,Kunjir, Sanil,Sanna Coccone, Salvatore,Brindisi, Margherita,Moretti, Vittoria,Brogi, Simone,Novellino, Ettore,Basilico, Nicoletta,Parapini, Silvia,Taramelli, Donatella,Campiani, Giuseppe,Butini, Stefania
, p. 5949 - 5953 (2011/10/09)
Here we report the synthesis and evaluation of antiplasmodial activity of a novel series of bicyclic peroxides inspired by the marine natural compound dihydroplakortin. We developed a synthetic strategy leading to the dihydroplakortin-related peroxides in only a few steps. The in vitro antiplasmodial potency of the peroxides was similar to, or greater than, that of the reference natural compound, and structure-activity relationship studies revealed several key structural requirements for activity and potency.
Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity
-
, (2008/06/13)
The compounds of Formula I are useful as immunosuppressive agents.
Immunosuppressant tricyclic compounds
-
, (2008/06/13)
The compounds of Formula I are useful as immunosuppressive agents.
Tetracyclic triterpene derivatives with immunosuppressant activity
-
, (2008/06/13)
The compounds of Formula I are useful as immunosuppressive agents.