28366-80-5Relevant academic research and scientific papers
The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: Its synthesis and immunomodulatory function
Arai, Yohei,Fujimoto, Yukari,Matsumaru, Takanori,Torigoe, Shota,Yamasaki, Sho
, p. 3659 - 3663 (2020/06/03)
Ac1PIM1is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) fromMycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.
Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols
Kubiak, Robert J.,Bruzik, Karol S.
, p. 960 - 968 (2007/10/03)
Studies of cellular signal transduction mechanisms involving receptor-mediated generation of inositol phosphates and phosphorylated phosphatidylinositols require easy access to these naturally occurring products. Although numerous synthetic methods have been developed during the past decade, most of these methods suffer from excessive length and lack of generality. In this work we describe the comprehensive and uniform synthesis of all naturally occurring phosphatidylinositols such as phosphatidylinositol, phosphatidylinositol 3-phosphate, 4-phosphate, 5-phosphate, 3,4-bisphosphate, 3,5-bisphosphate, 4,5-bisphosphate, and 3,4,5-trisphosphate, featuring both saturated and unsaturated fatty acid chains.
IMPROVED SYNThESES OF INOSITOL PHOSPHOLIPID ANALOGUES
Jones, Martin,Rana, Kishore K.,Ward, John G.,Young, Rodney C.
, p. 5353 - 5356 (2007/10/02)
Short and convenient syntheses of PtdIns 4P and PtdIns analogues based on selective phosphorylation of (+)-2,3:5,6-di-O-isopropylidine-myo-inositol are presented.
