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(2R,3R)-2,3-dihydroxybutane-1,4-diyl dinitrate, also known as isosorbide dinitrate, is a chemical compound derived from the sugar sorbitol. It is a white crystalline solid with the chemical formula C6H8N2O8. (2R,3R)-2,3-dihydroxybutane-1,4-diyl dinitrate is primarily used as a vasodilator in the treatment of angina pectoris and other cardiovascular conditions. Isosorbide dinitrate works by releasing nitric oxide, which helps to relax and widen blood vessels, thereby reducing the workload on the heart and improving blood flow. It is available in various pharmaceutical formulations, including tablets, capsules, and sublingual sprays, and is typically taken under the guidance of a healthcare professional to manage symptoms and prevent complications related to heart disease.

28368-55-0

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28368-55-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 28368-55-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,3,6 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 28368-55:
(7*2)+(6*8)+(5*3)+(4*6)+(3*8)+(2*5)+(1*5)=140
140 % 10 = 0
So 28368-55-0 is a valid CAS Registry Number.

28368-55-0Downstream Products

28368-55-0Relevant academic research and scientific papers

Tetranitromethane as an efficient reagent for the conversion of epoxides into β-hydroxy nitrates

Volkova, Yuliya A.,Ivanova, Olga A.,Budynina, Ekaterina M.,Averina, Elena B.,Kuznetsova, Tamara S.,Zefirov, Nikolai S.

, p. 3935 - 3938 (2008/09/21)

A convenient regioselective method for the preparation of β-hydroxy nitrates based on the ring opening reaction of epoxides by tetranitromethane in the presence of triethylamine is described. A series of substituted β-hydroxy nitrates were obtained in high yields under mild conditions.

NITRATION EQUILIBRIUM IN THE MESO-ERYTHRITOL-AQUEOUS NITRIC ACID SYSTEM

Kazakov, A. I.,Lagodzinskaya, G. V.,Yunda, N. G.,Andrienko, L. P.,Korolev, A. M.,et al.

, p. 1966 - 1971 (2007/10/02)

Twelve equilibrium constants have been measured from 16 for sequential-parallel reactions in meso-erythritol nitration to the fully nitrated compound in aqueous HNO3.Free-energy changes during nitration of the aliphatic polyatomic alcohols, glycerol and meso-erythritol, are highest when diprimary dinitrates (NOON) and (NON) are produced.

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