28369-98-4Relevant academic research and scientific papers
Synthesis method and application of 2-(2,6-dichlorophenoxy) pyridine compound
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Paragraph 0255-0265, (2017/08/30)
The invention relates to a synthesis method and application of a 2-(2,6-dichlorophenoxy) pyridine compound. In an organic solvent, 2-phenoxy pyridine and N-chlorosuccinimide are taken as reaction raw materials, and under the joint promotion effect of a tr
Regioselective C-H chlorination: Towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds
Gao, Chao,Li, Hongchen,Liu, Miaochang,Ding, Jinchang,Huang, Xiaobo,Wu, Huayue,Gao, Wenxia,Wu, Ge
, p. 46636 - 46643 (2017/10/16)
We have developed a protocol for the auxillary directed C-H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C-H functionalization reaction of phenol derivatives to produce a variety of symmetrical and unsymmetrical 2,4,6-trisubstituted phenols.
