2840-49-5Relevant academic research and scientific papers
N-Hydroxyphthalimide-Mediated Electrochemical Denitrogenation of Aroylhydrazides to Generate Acyl Radicals and Their Applications in the Syntheses of Fluorenones
Zhang, Haonan,Wang, Ting,Xu, Kun,Zeng, Chengchu
, p. 16171 - 16176 (2021/10/12)
N-Hydroxyphthalimide (NHPI)-mediated electrochemical denitrogenation of aroylhydrazides is developed for the first time. The in situ generated acyl radicals could be intramolecularly trapped to give fluorenones with high efficiencies. This electrochemical
Method for treating inflammation and compounds and compositions suitable for use therein
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, (2008/06/13)
The present invention relates to a method of treating an inflammatory condition, and to compounds and composition suitable for use in such a method, which compounds have the Formula: STR1 wherein: X is methylene, ethylene, ethyleneoxy, or oxygen; Q is STR2 where C' is a residue of a lipophilic amino acid, and Y is --CO2 H, --CH2 OH, --CONR1 R2, or --CO2 R1 where R1 and R2 hydrogen, alkyl, or aryl; R3 and R4 are, independently, hydrogen, alkyl or aryl; and A and B are, independently, hydrogen, fused phenyl, alkyl, aryl, alkaryl, aralkyl, alkoxy, alkoxyalkyl, halogen, or nitro; or pharmaceutically acceptable salts thereof.
An N.M.R. Investigation of the Mills-Nixon Effect
Collins, Michael J.,Gready, Jill E.,Sternhell, Sever,Tansey, Charles W.
, p. 1547 - 1557 (2007/10/02)
The 4J coupling constant, previously established as a probe of bond order, was used to examine the bond orders in a series of ortho-bridged compounds: benzocyclopropene, 1,2-dihydrobenzocyclobutene, indan and tetralin.No evidence for sterically induced bond fixation (i.e. the Mills-Nixon effect) was found, but some evidence for electronic distortion in the corresponding benzylic ketones was observed.The experimental results are in accord with SCF/MO calculations.
Versatile and Convenient Lattice Hosts derived from Singly Bridged Triarylmethane Frameworks, X-Ray Crystal Structures of Three Inclusion Compounds
Weber, Edwin,Doerpinghaus, Norbert,Csoeregh, Ingeborg
, p. 2167 - 2177 (2007/10/02)
A new family of host molecules, based on the singly bridged triarylmethanol and triarylacetic acid frameworks, is described.These hosts form crystalline inclusions with a variety of uncharged organic molecules ranging from protic dipolar to apolar compounds (130 different species).The formation and stoicheiometry depend in a systematic manner on structural parameters of the host, such as the nature of the functional group and the substituents, and on the substituent positions.The crystal structures of three inclusion compounds have been studied by X-ray diffraction.They reveal the building principles of the new inclusion family.In the crystals of 1a*benzene (8:3), the benzene is interstitially entrapped by H-bonded tetramer clusters of 1a.Crystals of 1a*dioxane (4:3) are built of H-bonded 2:1 host-guest complexes including interstitial molecules of dioxane.In the case of 4c*EtOH (1:1), the building principle is formation of 2:2 host-guest clusters via a twelve-membered H-bonded ring.
Transanular Interaction in Phanes, 27: Models for Excimers and Exciplexes: Phanes of Fluorene, 9-Fluorenone, and 9-Fluorenyl Anion
Haenel, Matthias W.,Irngartinger, Hermann,Krieger, Claus
, p. 144 - 162 (2007/10/02)
anti- and syn-(2,7)-fluorenophane (1, 2) as well as their 5,16-dioxo and 5-oxo derivatives 3, 5, and 6 containing two or one 9-fluorenone units were synthesized: Cyclisation of the bis(bromomethyl) compounds 7 and 10 with the bis(mercaptomethyl) compounds 9 and 12 gave the dithiaphanes 14, 16, and 18 containing fluorene and 9-fluorenone units bridged at the 2,7-positions.Oxidation to the disulfones 15, 17, and 18 and vapour phase pyrolysis (500 degC, 0.1 Torr) led to 1/2, 3, and 5/6, respectively.The molecular geometry of 1 was determined by X-ray structure analysis.On treatment of suspensions of 1 and 2 in hexamethylphosphoric triamide with n-butyllithium in n-hexane red solutions of the dianions 21 and 22 were generated, which were characterized by 1H NMR spectroscopy.With deuterium oxide the dianion 22 yielded 2>-anti-(2,7)fluorenophane (24), with methyl iodide exo-5,exo-16-dimethyl-anti-(2,7)fluorenophane (26).Multiple metalation with n-butyllithium and reaction with methyl iodide led to 5,5,16,16-tetramethyl-anti-(2,7)flourenophane (27).
