1504-75-2

Basic information

• Product Name: 2-Propenal, 3-(4-methylphenyl)-
• Synonyms: 2-Propenal, 3-(4-methylphenyl)-;PARA-METHYLCINNAMALDEHYDE;3-(p-Tolyl)acrylaldehyde
• CAS NO: 1504-75-2
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.19
• Mol File: 1504-75-2.mol
• Article Data: 37

Chemical Properties

• Melting Point: 41.5°C
• Boiling Point: 225.81°C (rough estimate)
• Flash Point: 94.3°C
• Appearance: /
• Density: 0.9670
• Vapor Pressure: 0.00856mmHg at 25°C
• Refractive Index: 1.5876 (estimate)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-Propenal, 3-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 3-(4-methylphenyl)-(1504-75-2)
• EPA Substance Registry System: 2-Propenal, 3-(4-methylphenyl)-(1504-75-2)

Safety Data

• Hazardous Substances Data: 1504-75-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 349, 1990 DOI: 10.1016/S0040-4039(00)94552-0

InChI:InChI=1/C10H10O/c1-9-4-6-10(7-5-9)3-2-8-11/h2-8H,1H3

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 75-07-0 acetaldehyde 
• 58824-48-9 1-(4-methylphenyl)-2-propen-1-ol 
• 10035-10-6 hydrogen bromide 
• 7789-60-8 phosphorus tribromide 
• 624-31-7 4-tolyl iodide 
• 107-18-6 allyl alcohol 
• 132589-36-7 1-(4-methylphenyl)prop-2-yn-1-ol 
• 1866-39-3 4-methylcinnamic acid 
• 2698-14-8 1-methyl-4-(prop-1-enyl)benzene 
• 20511-20-0 ethyl p-methylcinnamate 
• 179249-12-8 (1S)-(+)-1-(4'-methylphenyl)-2-propynol 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 75-27-4 bromodichloromethane 

Downstream Products

• 92807-31-3 (4E,6E)-1,1-Bis-methylsulfanyl-7-p-tolyl-hepta-1,4,6-trien-3-one 
• 99048-63-2 (4E,6E)-2-Methyl-1,1-bis-methylsulfanyl-7-p-tolyl-hepta-1,4,6-trien-3-one 
• 93626-89-2 1-methyl-5-p-tolyl-2-aza-1-oxapentadiene 
• 2840-49-5 2,7-dimethyl-9H-fluoren-9-one 
• 16191-28-9 2-(4-methylphenyl)benzaldehyde 
• 1013889-12-7 1-(4-methyl-phenyl)-4-methyl-penta-1,4-dien-3-ol 
• 99048-67-6 (4E,6E)-1,1-Bis-methylsulfanyl-7-p-tolyl-hepta-1,4,6-trien-3-ol 
• 99048-71-2 (4E,6E)-2-Methyl-1,1-bis-methylsulfanyl-7-p-tolyl-hepta-1,4,6-trien-3-ol 
• 13677-51-5 1,3-bis(4-methylphenyl)prop-2-en-1-ol 
• 1095532-24-3 (2S,3R)-2-(benzylthio)-3-(2,5-dioxopyrrolidin-1-yl)-3-p-tolylpropanal 
• 1032816-25-3 C₁₅H₁₆O₂ 
• 1154760-53-8 C₁₁H₁₁NO₃ 
• 1154760-72-1 C₁₁H₁₁NO₃ 
• 1100803-88-0 methyl 2-((1S,2S,3R,4R)-2-formyl-4-nitro-3-p-tolylcyclopentyl)acetate 

Relevant articles and documents

Asymmetric Synthesis of Functionalized 9-Methyldecalins Using a Diphenylprolinol-Silyl-Ether-Mediated Domino Michael/Aldol Reaction

Substituted 9-methyldecalin derivatives containing an all carbon quaternary chiral center were synthesized with excellent enantioselectivity via an organocatalyst-mediated domino reaction. The first reaction is a diphenylprolinol silyl ether-mediated Michael reaction, and the second reaction is an intramolecular aldol reaction. The enantiomerically pure catalyst is involved in both reactions.

Regioselective Silylations of Propargyl and Allyl Pivalates through Ca-Promoted Reductive C(sp3)-O Bond Cleavage

A practical protocol for the regioselective preparation of 3-phenylpropargylsilanes and 3-phenylallylsilanes in yields of 36-77 and 48-86%, respectively, from readily accessible 3-phenylpropargyl and 1-phenylallyl pivalates was developed through reductive C(sp3)-O bond cleavage. This method represents the first example of the direct application of vastly abundant calcium granules to a reductive coupling reaction. A broad range of propargylsilanes and allylsilanes are simply prepared using easy-to-handle pivalates and chlorotrimethylsilane under mild catalyst-free and additive-free conditions.

Highly Regio- A nd Enantioselective Hydrogenation of Conjugated α-Substituted Dienoic Acids

Highly regio- A nd enantioselective hydrogenation of conjugated α-substituted dienoic acids was realized for the first time using Trifer-Rh complex, providing a straightforward method for the synthesis of chiral α-substituted ?,?′-unsaturated acids. DFT calculations revealed N+H-O hydrogen bonding interaction is formed to stabilize the transition state and the coordination of 4,5-double bond to Rh(III) center would facilitate the reductive elimination process. This hydrogenation provided a gram-scale synthesis of the precursor of sacubitril.