284043-08-9

Basic information

• Product Name: γ-O-(3,5-dimethoxy-4-hydroxyphenacyl) t-butyl N-t-boc L-glutamate
• Synonyms: γ-O-(3,5-dimethoxy-4-hydroxyphenacyl) t-butyl N-t-boc L-glutamate
• CAS NO: 284043-08-9
• Molecular Weight: 497.543
• Mol File: 284043-08-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: γ-O-(3,5-dimethoxy-4-hydroxyphenacyl) t-butyl N-t-boc L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: γ-O-(3,5-dimethoxy-4-hydroxyphenacyl) t-butyl N-t-boc L-glutamate(284043-08-9)
• EPA Substance Registry System: γ-O-(3,5-dimethoxy-4-hydroxyphenacyl) t-butyl N-t-boc L-glutamate(284043-08-9)

Safety Data

• Hazardous Substances Data: 284043-08-9(Hazardous Substances Data)

Upstream product

• 2478-38-8 1-(4-hydroxy-3,5-dimethoxy-phenyl)-ethanone 
• 51149-28-1 2-bromo-1-(4-hydroxy-3,5-dimethoxyphenyl)ethanone 
• 24277-39-2 N-tert-butoxycarbonyl glutamic acid tert-butyl ester 

Downstream Products

• 90426-22-5 3',5'-dimethoxy-4'-hydroxy-(2-hydroxy)acetophenone 
• 2478-38-8 1-(4-hydroxy-3,5-dimethoxy-phenyl)-ethanone 

Relevant articles and documents

New Phototriggers: Extending the p-Hydroxyphenacyl π-π* Absorption Range

(Matrix Presented) Introducing 3-methoxy or 3,5-dimethoxy substituents on the 4-hydroxyphenacyl (pHP) photoremovable protecting group has been explored with two excitatory γ-amino acids, L-glutamic acid and γ-amino butyric acid (GABA). These substituents significantly extend the absorption range of the pHP chromophore, e.g., the tail of absorption bands of 2a,b extend above 400 nm, well beyond the absorptions of aromatic amino acids and nucleotides. Irradiation releases the amino acids with rate constants of ～107 s-1 and appearance efficiencies (Φapp) of 0.03-0.04. The photoproducts are formed through the pHP excited triplet and are primarily products of photoreduction and photohydrolysis. 1a,b also rearranged to the phenylacetic acid 3.