284046-13-5

Upstream product

• 56764-09-1 1,5-dimethyl-2-(1-methylethylidene)cyclohexan-1-ol 
• 89-82-7 pulegone 

Downstream Products

• 443883-50-9 (1S,2R,5R)-1,2-di[(tert-butyldimethylsilyl)oxy]-3,5-dimethyl-3-cyclohexene 
• 128441-46-3 (S)-3,5-dimethylhexenone 
• 443883-72-5 (1S,5S)-3,5-Dimethyl-cyclohex-2-enol 

Relevant academic research and scientific papers

A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

The stereoselective synthesis of the spiroketal fragment 4a and its C1″-epimer 4b of the HIV-1 protease inhibitors didemnaketals has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers by intramolecular chiral induction.

Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthetic approach to the key mother spiroketals.

The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1'R,1' 'R)-2(acetylhydroxymethyl)-4,10-dimethyl-8(isopropenylhydroxymethyl)-1,7-dioxaspiro[5,5]undecane (4a) and its C1' '-epimer (4b), the key mother spiroketals of the HIV-1 protease inhibitive didemnaketals from the ascidian Didemnum sp., has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers(C-2, C-6, C-8, and C-1') by intramolecular chiral induce.