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28416-82-2

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  • High quality (6A,11B,16A,17A)-6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxoandrosta-1 supplier in China

    Cas No: 28416-82-2

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  • Simagchem Corporation
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  • High purity (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid CAS No.:28416-82-2

    Cas No: 28416-82-2

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  • (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihyroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid

    Cas No: 28416-82-2

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28416-82-2 Usage

Description

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid, also known as Fluticasone 17β-carboxylic acid, is a white solid intermediate in the synthesis of the glucocorticosteroid Fluticasone propionate. It is a major metabolite of Fluticasone and possesses anti-inflammatory properties.

Uses

Used in Pharmaceutical Industry:
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid is used as an intermediate in the synthesis of Fluticasone propionate for its anti-inflammatory properties. It plays a crucial role in the development of medications that help reduce inflammation and alleviate symptoms associated with various conditions, such as asthma, allergies, and other inflammatory diseases.
Used in Anti-inflammatory Applications:
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid is used as an anti-inflammatory agent due to its ability to reduce inflammation and provide relief from various conditions. Its incorporation in pharmaceutical products helps manage symptoms and improve the quality of life for patients suffering from inflammatory disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 28416-82-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,4,1 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 28416-82:
(7*2)+(6*8)+(5*4)+(4*1)+(3*6)+(2*8)+(1*2)=122
122 % 10 = 2
So 28416-82-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H26F2O5/c1-10-6-12-13-8-15(22)14-7-11(24)4-5-18(14,2)20(13,23)16(25)9-19(12,3)21(10,28)17(26)27/h4-5,7,10,12-13,15-16,25,28H,6,8-9H2,1-3H3,(H,26,27)/t10-,12+,13+,15+,16+,18+,19+,20+,21+/m1/s1

28416-82-2 Well-known Company Product Price

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  • (1285818)  Fluticasone propionate Related Compound J  United States Pharmacopeia (USP) Reference Standard

  • 28416-82-2

  • 1285818-15MG

  • 14,500.98CNY

  • Detail

28416-82-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid

1.2 Other means of identification

Product number -
Other names (6S,8S,9R,10S,11S,13R,14S,17S)-17-acetyl-6,9-difluoro-11-hydroxy-10,13-dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanth ren-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28416-82-2 SDS

28416-82-2Relevant articles and documents

GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF

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Paragraph 0102-0103, (2021/08/20)

Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, pharmaceutical compositiosn including the same, and methods of using the same.

Preparation method of fluticasone propionate intermediate

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Paragraph 0036-0081, (2020/07/13)

The invention discloses a preparation method of a fluticasone propionate intermediate. The preparation method comprises the following steps: firstly, preparing silica gel loaded sodium periodate, andthen oxidizing flumetasone by utilizing the silica gel loaded sodium periodate so as to obtain a fluticasone propionate intermediate 6alpha, 9alpha-difluoro-11beta, 17alpha-dyhydroxy-16alpha-methyl-3-oxoandrostane-1, 4-diene-17beta-carboxylic acid. The method has the advantages of readily available reaction raw materials, simple operation, good selectivity, no by-product, stable process, low price, safety, high reaction yield and the like and is beneficial to reduction of the production cost of enterprises and subsequent commercial production and batch supply.

POTENT SOFT ANTI-INFLAMMATORY CORTICOSTEROID COMPOUNDS AND USES THEROF

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Paragraph 0070; 0081; 0082, (2019/01/08)

Potent soft corticosteroid pharmaceutical compositions comprising them and method for use as anti-inflammatory agents. Also, a method for softening fluticasone propionate and similar corticosteroids to arrive at potent but safer alternatives. The compound S-fluoromethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16a- methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, which is equally potent to but safer than fluticasone, is among those provided. Another compound of particular interest is 2-hydroxyethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16β- methyl-3-oxoandrosta-1,4-diene-17β-carboxylate.

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