28416-82-2Relevant articles and documents
GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF
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Paragraph 0102-0103, (2021/08/20)
Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, pharmaceutical compositiosn including the same, and methods of using the same.
Preparation method of fluticasone propionate intermediate
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Paragraph 0036-0081, (2020/07/13)
The invention discloses a preparation method of a fluticasone propionate intermediate. The preparation method comprises the following steps: firstly, preparing silica gel loaded sodium periodate, andthen oxidizing flumetasone by utilizing the silica gel loaded sodium periodate so as to obtain a fluticasone propionate intermediate 6alpha, 9alpha-difluoro-11beta, 17alpha-dyhydroxy-16alpha-methyl-3-oxoandrostane-1, 4-diene-17beta-carboxylic acid. The method has the advantages of readily available reaction raw materials, simple operation, good selectivity, no by-product, stable process, low price, safety, high reaction yield and the like and is beneficial to reduction of the production cost of enterprises and subsequent commercial production and batch supply.
POTENT SOFT ANTI-INFLAMMATORY CORTICOSTEROID COMPOUNDS AND USES THEROF
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Paragraph 0070; 0081; 0082, (2019/01/08)
Potent soft corticosteroid pharmaceutical compositions comprising them and method for use as anti-inflammatory agents. Also, a method for softening fluticasone propionate and similar corticosteroids to arrive at potent but safer alternatives. The compound S-fluoromethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16a- methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, which is equally potent to but safer than fluticasone, is among those provided. Another compound of particular interest is 2-hydroxyethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16β- methyl-3-oxoandrosta-1,4-diene-17β-carboxylate.