73205-13-7

Basic information

• Product Name: Ticabesone Propionate
• Synonyms: Ticabesone Propionate;Androsta-1,4-diene-17- carbothioic acid,6,9-difluoro-11- hydroxy-16-Methyl-3-oxo-17-(1- oxopropoxy)-, S-Methyl ester, (6α,11β,16α,17α)-;6α,9-Difluoro-17-[(methylsulfanyl)carbonyl]-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-dien-17α-yle propanoate;Fluticasone Methylsulphanyl Analog;Fluticasone Propinate EP impurity D
• CAS NO: 73205-13-7
• Molecular Formula: C25H32F2O5S
• Molecular Weight: 482.5803864
• Mol File: 73205-13-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 569.4°Cat760mmHg
• Flash Point: 298.2°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 2.46E-15mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 12.56±0.70(Predicted)
• CAS DataBase Reference: Ticabesone Propionate(CAS DataBase Reference)
• NIST Chemistry Reference: Ticabesone Propionate(73205-13-7)
• EPA Substance Registry System: Ticabesone Propionate(73205-13-7)

Safety Data

• Hazardous Substances Data: 73205-13-7(Hazardous Substances Data)

Usage

Description

Ticabesone Propionate is a chemical compound that serves as an impurity in Fluticasone, a medication known for its antiallergic, anti-asthmatic, and anti-inflammatory properties. It is a derivative of the corticosteroid class, which is commonly used to treat a variety of respiratory conditions, skin disorders, and allergic reactions.

Uses

Used in Pharmaceutical Industry:
Ticabesone Propionate is used as an impurity in Fluticasone for its antiallergic, anti-asthmatic, and anti-inflammatory effects. It is important to monitor and control the levels of this impurity in Fluticasone to ensure the safety and efficacy of the medication. Fluticasone works by reducing inflammation and swelling, which helps alleviate symptoms associated with allergies, asthma, and other inflammatory conditions.

InChI:InChI=1/C25H32F2O5S/c1-6-20(30)32-25(21(31)33-5)13(2)9-15-16-11-18(26)17-10-14(28)7-8-22(17,3)24(16,27)19(29)12-23(15,25)4/h7-8,10,13,15-16,18-19,29H,6,9,11-12H2,1-5H3/t13-,15?,16?,18+,19+,22?,23+,24+,25+/m1/s1

Upstream product

• 5188-07-8 sodium thiomethoxide 
• 65429-42-7 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-carboxylic acid 
• 2557-49-5 11β,17α,21-trihydroxy-6α,9α-difluoro-16β-methylpregna-1,4-diene-3,20-dione 
• 28416-82-2 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid 
• 73205-12-6 Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-(diethoxy-phosphoryloxycarbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester 

Relevant articles and documents

Process for the preparation of steroidal 17 beta-carbothioates

A novel method for the conversion of steroidal 17β-carboxylic acids to carbothioates such as fluticasone propionate via novel in situ generated 17β-carboxy imidazolyl- or succinimidyl esters.