28434-93-7Relevant academic research and scientific papers
Chloroindate(iii) ionic liquids as catalysts for alkylation of phenols and catechol with alkenes
Gunaratne, H. Q. Nimal,Lotz, Tobias J.,Seddon, Kenneth R.
scheme or table, p. 1821 - 1824 (2011/01/07)
Chloroindate(iii) ionic liquids are shown to be versatile catalysts for the alkylation of phenols with alkenes, giving high conversions to alkylated phenols with high selectivities.
ALKYLATION OF HYDROXYARENES WITH OLEFINS, ALCOHOLS AND ETHERS IN IONIC LIQUIDS
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Page/Page column 20-21, (2008/06/13)
Hydroxyarenes are alkylated using an ionic liquid catalyst system with olefins, alcohols, or ethers as alkylating agents. The ionic liquid catalyst system comprises chloroindate (III) anions. The reactions may be conducted at moderate temperatures and pressures to yield commercially relevant alkylated hydroxyarene compounds.
Synthesis of three naturally occuring diisopropylmethylphenols
Ramanamma, C. V.,Dinge, A. S.,Paknikar, S. K.
, p. 517 - 519 (2007/10/02)
Synthesis of 2,6-diisopropyl-3-methylphenol (1), 2,4-diisopropyl-5-methylphenol (2) and 2,5-diisopropyl-4-methylphenol (3) is described.These synthetic phenols have been shown to be identical with the corresponding C13-phenols isolated from Corodothymus capitatus thus confirming the assigned structures.
Synthesis, Biological Evaluation, and Preliminary Structure-Activity Considerations of a Series of Alkylphenols as Intravenous Anesthetic Agents
James, Roger,Glen, John B.
, p. 1350 - 1357 (2007/10/02)
Following our discovery of the intravenous (iv) anesthetic activity of 2,6-diethylphenol in mice, a series of alkylphenols was examined in this species and the most active analogues were further evaluated in rabbits.The synthesis of compounds which were not commercially available was accomplished by adaptations of standard ortho-alkylation procedures for phenols.Structure-activity relationships were found to be complex, but, in general, potency and kinetics appeared to be a function of both the lipophilic character and the degree of steric hindrance exerted by ortho substituents.The most interesting compounds were found in the 2,6-dialkyl series, and the greatest potency was associated with 2,6-di-sec-alkyl substitution.In particular, 2,6-diisopropylphenol (ICI 35868) emerged as a candidate for further development and has subsequently been shown to be an effective iv anesthetic agent in man.
