28440-63-3Relevant academic research and scientific papers
2-[(arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding
Bair,Andrews,Tuttle,Knick,Cory,McKee
, p. 1983 - 1990 (2007/10/02)
The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA binding in a series of carbocyclic 2-[(arylmethyl)amino]-2-methyl-1,3-propanediols (AMAPs) were examined. In general, the interaction of AMAPs wit
Policyclic Fluoranthene Hydrocarbons. 2. A New General Synthesis
Cho, Bongsup P.,Harvey, Ronald G.
, p. 5668 - 5678 (2007/10/02)
A novel and efficient synthetic approach to policyclic fluoranthene hydrocarbons is described.The method entails fusion of an indeno ring to an appropriate alternant hydrocarbon via reaction of its aryllithium derivative with cyclohexene oxide, followed by oxidation, cyclodehydration, and aromatization.Cyclization of the cyclohexanone and cyclohexanol derivatives of the policyclic aromatic ring systems studied proceeds with high regioselectivity, and the direction of ring closure is predictable by molecular orbital methods.This synthetic approach provides a convenient general route to polyaromatic fluoranthene compounds, including potentially carcinogenic members of this class.Hydrocarbons synthesized by this method include benzacephenanthrylene (1), indenopyrene (2), indenochrysene (3), benzindenochrysene (4), fluorenochrysene (5), dibenzaceanthrylene (6), dibenzaceanthrylene (7), benzaceanthrylene (8), benzindenochrysene (9), fluorenochrysene (10), and dibenzacephenanthrylene (11).
