284462-86-8

Basic information

• Product Name: 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N,N-dimethyl-
• CAS NO: 284462-86-8
• Molecular Formula: C14H15N3O2
• Molecular Weight: 257.292
• Mol File: 284462-86-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N,N-dimethyl-(284462-86-8)
• EPA Substance Registry System: 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N,N-dimethyl-(284462-86-8)

Safety Data

• Hazardous Substances Data: 284462-86-8(Hazardous Substances Data)

Upstream product

• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 373-68-2 tetramethylammonium fluoride 
• 114780-06-2 4-chloro-N,N-dimethylpyridine-2-carboxamide 
• 123-30-8 4-amino-phenol 
• 220000-87-3 4-chloro-N-methylpicolinamide 

Downstream Products

• 75919-92-5 1-(4-(4-nitrophenoxy)phenyl)ethanone 
• 284462-54-0 4-(1-oxoisoindolin-5-yloxy)aniline 
• 220000-87-3 4-chloro-N-methylpicolinamide 

Relevant articles and documents

Selective Methylation of Amides, N-Heterocycles, Thiols, and Alcohols with Tetramethylammonium Fluoride

We herein disclose the use of tetramethylammonium fluoride (TMAF) as a direct and selective methylating agent of a variety of amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The method is characterized by operational simplicity, wide scope, and ease of purification. Our computational studies suggest a concerted methylation-deprotonation as the preferred reaction pathway.

OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.