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4-Chloro-N,N-Dimethyl-Pyridine-2-Carboxamide, with the CAS Registry Number 3222-52-6, is a yellow solid chemical compound belonging to the class of carboxamides and pyridines. It is used in the field of biochemistry, particularly for scientific research and the synthesis of complex compounds and drugs. 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE is moderately toxic upon ingestion, inhalation, or skin contact, and is combustible. It does not significantly react with water and should be stored in a well-ventilated, cool, and dry place. Proper handling and safety measures are essential to prevent adverse health effects.

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  • 114780-06-2 Structure
  • Basic information

    1. Product Name: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE
    2. Synonyms: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE;4-Chloro-N,N-dimethylpicolinamide;2-Pyridinecarboxamide, 4-chloro-N,N-dimethyl-
    3. CAS NO:114780-06-2
    4. Molecular Formula: C8H9ClN2O
    5. Molecular Weight: 184.62
    6. EINECS: N/A
    7. Product Categories: Pyridines
    8. Mol File: 114780-06-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 323.5 °C at 760 mmHg
    3. Flash Point: 149.4 °C
    4. Appearance: /
    5. Density: 1.231 g/cm3
    6. Vapor Pressure: 0.000261mmHg at 25°C
    7. Refractive Index: 1.548
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. PKA: 0.67±0.10(Predicted)
    11. CAS DataBase Reference: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE(114780-06-2)
    13. EPA Substance Registry System: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE(114780-06-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 114780-06-2(Hazardous Substances Data)

114780-06-2 Usage

Uses

Used in Scientific Research:
4-Chloro-N,N-Dimethyl-Pyridine-2-Carboxamide is used as a research chemical for the synthesis of other complex compounds and drugs. It plays a crucial role in the development of new pharmaceuticals and bioactive molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 4-Chloro-N,N-Dimethyl-Pyridine-2-Carboxamide is used as an intermediate or building block in the synthesis of various drugs. Its unique chemical structure allows for the creation of new therapeutic agents with potential applications in medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 114780-06-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,7,8 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 114780-06:
(8*1)+(7*1)+(6*4)+(5*7)+(4*8)+(3*0)+(2*0)+(1*6)=112
112 % 10 = 2
So 114780-06-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClN2O/c1-11(2)8(12)7-5-6(9)3-4-10-7/h3-5H,1-2H3

114780-06-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloro-N,N-dimethylpyridine-2-carboxamide

1.2 Other means of identification

Product number -
Other names 4-Chloro-N,N-dimethylpicolinamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114780-06-2 SDS

114780-06-2Relevant articles and documents

3-Aryl-1,2,4-oxadiazole Derivatives Active Against Human Rhinovirus

Kim, Jinwoo,Shin, Jin Soo,Ahn, Sunjoo,Han, Soo Bong,Jung, Young-Sik

, p. 667 - 672 (2018/05/14)

The human rhinovirus (hRV) is the causative agent of the common cold that often aggravates respiratory complications in patients with asthma or chronic obstructive pulmonary disease. The high rate of mutations and variety of serotypes are limiting the development of anti-hRV drugs, which emphasizes the need for the discovery of novel lead compounds. Previously, we identified antiviral compound 1 that we used here as the starting material for developing a novel compound series with high efficacy against hRV-A and -B. Improved metabolic stability was achieved by substituting an ester moiety with a 1,2,4-oxadiazole group. Specifically, compound 3k exhibited a high efficacy against hRV-B14, hRV-A21, and hRV-A71, with EC50 values of 66.0, 22.0, and 3.7 nM, respectively, and a relevant hepatic stability (59.6 and 40.7% compound remaining after 30 min in rat and human liver microsomes, respectively). An in vivo study demonstrated that 3k possessed a desirable pharmacokinetic profile with low systemic clearance (0.158 L·h-1·kg-1) and modest oral bioavailability (27.8%). Hence, 3k appears to be an interesting candidate for the development of antiviral lead compounds.

SORAFENIB ANALOGS AND USES THEREOF

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Paragraph 0133; 0136, (2015/04/22)

The present invention provides, inter alia, compounds according to formula I. Also provided are pharmaceutical compositions and kits containing such compounds. Methods for using such compounds, compositions, and kits for treating a subject having system xc-, dysregulation for activating ferroptosis, for inhibiting system xc- in a cell, and for monitoring treatment of a subject having system xc- dysregulation are provided as well.

Substituted benzazoles and methods of their use as inhibitors of Raf kinase

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Page 248, (2008/06/13)

New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS

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Page/Page column 24, (2010/01/31)

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

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