114780-06-2

Basic information

• Product Name: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE
• Synonyms: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE;4-Chloro-N,N-dimethylpicolinamide;2-Pyridinecarboxamide, 4-chloro-N,N-dimethyl-
• CAS NO: 114780-06-2
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62
• Product Categories: Pyridines
• Mol File: 114780-06-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• Appearance: /
• Density: 1.231 g/cm³
• Vapor Pressure: 0.000261mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.67±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE(114780-06-2)
• EPA Substance Registry System: 4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE(114780-06-2)

Safety Data

• Hazardous Substances Data: 114780-06-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-N,N-Dimethyl-Pyridine-2-Carboxamide, also known by its CAS Registry Number 3222-52-6, is a chemical compound notable for its use in the field of biochemistry. This solid substance is yellow in colour and falls under the category of carboxamides and pyridines. It is moderately toxic upon ingestion, inhalation, or skin contact. The compound is combustible but does not significantly react with water, and it needs to be properly stored in a well-ventilated, cool and dry place. It's mostly used in scientific research, particularly in the synthesis of other complex compounds and drugs. As with any other substances with potential toxicity, handling this chemical requires utmost care and proper safety measures to prevent any adverse health effects.

InChI:InChI=1/C8H9ClN2O/c1-11(2)8(12)7-5-6(9)3-4-10-7/h3-5H,1-2H3

Upstream product

• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 124-40-3 dimethyl amine 
• 98-98-6 2-Picolinic acid 
• 220000-87-3 4-chloro-N-methylpicolinamide 
• 74-88-4 methyl iodide 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 

Downstream Products

• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 284462-86-8 4-(4-aminophenoxy)-N,N-dimethylpicolinamide 
• 611226-20-1 4-(4-Amino-3-nitro-phenoxy)-pyridine-2-carboxylic acid dimethylamide 

Relevant articles and documents

3-Aryl-1,2,4-oxadiazole Derivatives Active Against Human Rhinovirus

The human rhinovirus (hRV) is the causative agent of the common cold that often aggravates respiratory complications in patients with asthma or chronic obstructive pulmonary disease. The high rate of mutations and variety of serotypes are limiting the development of anti-hRV drugs, which emphasizes the need for the discovery of novel lead compounds. Previously, we identified antiviral compound 1 that we used here as the starting material for developing a novel compound series with high efficacy against hRV-A and -B. Improved metabolic stability was achieved by substituting an ester moiety with a 1,2,4-oxadiazole group. Specifically, compound 3k exhibited a high efficacy against hRV-B14, hRV-A21, and hRV-A71, with EC50 values of 66.0, 22.0, and 3.7 nM, respectively, and a relevant hepatic stability (59.6 and 40.7% compound remaining after 30 min in rat and human liver microsomes, respectively). An in vivo study demonstrated that 3k possessed a desirable pharmacokinetic profile with low systemic clearance (0.158 L·h-1·kg-1) and modest oral bioavailability (27.8%). Hence, 3k appears to be an interesting candidate for the development of antiviral lead compounds.

Substituted benzazoles and methods of their use as inhibitors of Raf kinase

New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.