284469-96-1

Basic information

• Product Name: N^α-Cbz-N^ε-formyl-N^ε-[[2-(trimethylsilyl)ethoxy]methoxy]-D-lysine methyl ester
• Synonyms: N^α-Cbz-N^ε-formyl-N^ε-[[2-(trimethylsilyl)ethoxy]methoxy]-D-lysine methyl ester
• CAS NO: 284469-96-1
• Molecular Weight: 468.623
• Mol File: 284469-96-1.mol

Chemical Properties

• CAS DataBase Reference: N^α-Cbz-N^ε-formyl-N^ε-[[2-(trimethylsilyl)ethoxy]methoxy]-D-lysine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-Cbz-N^ε-formyl-N^ε-[[2-(trimethylsilyl)ethoxy]methoxy]-D-lysine methyl ester(284469-96-1)
• EPA Substance Registry System: N^α-Cbz-N^ε-formyl-N^ε-[[2-(trimethylsilyl)ethoxy]methoxy]-D-lysine methyl ester(284469-96-1)

Safety Data

• Hazardous Substances Data: 284469-96-1(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 284469-94-9 C₁₈H₂₆N₂O₅ 
• 284469-95-0 N^α-Cbz-N^ε-hydroxy-N^ε-formyl-D-lysine methyl ester 

Downstream Products

• 284470-02-6 6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-2-{[2-(2-hydroxy-5-methoxy-phenyl)-5-methyl-oxazole-4-carbonyl]-amino}-hexanoic acid 1-{1-[1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester 
• 284470-01-5 (R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester 
• 1027428-89-2 (R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester 
• 225505-59-9 amamistatin A 
• 937242-43-8 (R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid 

Relevant articles and documents

Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment

A synthesis of brasilibactin A, a cytotoxic siderophore from the actinomycete of Nocardia brasiliensis, and three unnatural diastereomers of the natural product is described. Four possible diastereomers of the β-hydroxy acid fragment were prepared via asy

Total synthesis of amamistatin A, an antiproliferative linear peptide from an actinomycete

Amamistatin A, a linear lipopeptide and a growth inhibitor of human tumor cell lines from an actinomycete, was efficiently synthesized by a convergent approach. The asymmetric synthesis of β-hydroxy acid fragment was achieved by using chiral oxazaborolidinone mediated aldol reaction. The oxazole ring was constructed from N-acylthreonine via side-chain oxidation and cyclodehydration. The synthesis of the linear peptide was carded out in a stepwise manner from the cyclic hydroxamic acid fragment, and the final deprotection provided amamistatin A. (C) 2000 Elsevier Science Ltd.