284469-98-3

Upstream product

• 53985-53-8 2-(benzyloxy)-5-methoxybenzoic acid 
• 284469-97-2 N-(2-benzyloxy-5-methoxy)benzoyl-L-threonine methyl ester 
• 54625-34-2 2-benzyloxy-5-methoxy benzoic acid benzyl ester 
• 706821-99-0 2-benzyloxy-5-methoxybenzamide 
• 100-39-0 benzyl bromide 
• 2612-02-4 5-methoxysalicylic acid 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 706822-03-9 2-benzyloxy-5-methoxy-N-(1-methoxycarbonyl-2-oxopropyl)benzamide 

Downstream Products

• 284470-02-6 6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-2-{[2-(2-hydroxy-5-methoxy-phenyl)-5-methyl-oxazole-4-carbonyl]-amino}-hexanoic acid 1-{1-[1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester 
• 284469-89-2 2-[(2-hydroxy-5-methoxy)phenyl]-5-methyloxazole-4-caboxylic acid 
• 225505-59-9 amamistatin A 
• 284469-99-4 methyl 2-[(2-hydroxy-5-methoxy)phenyl]-5-methyloxazole-4-caboxylate 

Relevant academic research and scientific papers

N-H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles

Dirhodium(II) carboxylate catalysed reaction of diazocarbonyl compounds 2 in the presence of primary amides 1 results in the formation of α-acylaminoketones 3 (12 examples) by N-H insertion reaction of the intermediate rhodium carbene. The 1,4-dicarbonyl

Total synthesis of amamistatin A, an antiproliferative linear peptide from an actinomycete

Amamistatin A, a linear lipopeptide and a growth inhibitor of human tumor cell lines from an actinomycete, was efficiently synthesized by a convergent approach. The asymmetric synthesis of β-hydroxy acid fragment was achieved by using chiral oxazaborolidinone mediated aldol reaction. The oxazole ring was constructed from N-acylthreonine via side-chain oxidation and cyclodehydration. The synthesis of the linear peptide was carded out in a stepwise manner from the cyclic hydroxamic acid fragment, and the final deprotection provided amamistatin A. (C) 2000 Elsevier Science Ltd.