28448-83-1

Upstream product

• 128961-25-1 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 870-63-3 prenyl bromide 
• 28437-37-8 5-C-prenylresacetophenone 
• 77-78-1 dimethyl sulfate 
• 87080-11-3 2,4-Dimethoxy-5-C-prenylacetophenone 

Downstream Products

• 128961-13-7 (E)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl)-3-(4-(methoxymethoxy)phenyl)prop-2-en-1-one 
• 129097-15-0 2-(4-hydroxyphenyl)-7-methoxy-6-(3-methylbut-2-en-1-yl)chroman-4-one 
• 128961-19-3 7-methoxy-2-(4-(methoxymethoxy)phenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one 
• 869561-89-7 C₁₄H₁₉NO₃ 
• 20784-60-5 (E)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 126829-44-5 2'-Hydroxy-4'-methoxy-5'-C-prenylchalkon 
• 1622397-93-6 (E)-3-(4'-fluoro-4-biphenylyl)-1-(2-hydroxy-4-methoxyphenyl)2-propen-1-one 
• 1622397-81-2 (E)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)-3-p-tolyl prop-2-en-1-one 
• 1622397-89-0 (2Z)-6-methoxy-5-(3-methylbut-2-enyl)-2-(p-tolylmethylene)benzofuran-3-one 
• 1622397-82-3 (E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)prop-2-en-1-one 
• 1622397-91-4 (2Z)-2-[(3,4-dimethoxyphenyl)methylene]-6-methoxy-5-(3-methylbut-2-enyl)benzofuran-3-one 
• 1622397-85-6 C₃₁H₃₈O₇ 
• 1622397-87-8 (E)-3-(3,4-dihydroxyphenyl)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)prop-2-en-1-one 
• 1622397-83-4 (E)-3-(4-bromophenyl)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

2-phenylchroman-4-one derivatives and antiviral composition comprising the same

The present invention relates to a 2-phenylchroman-4-one derivative or a pharmaceutically acceptable salt thereof, a method for manufacturing the same, and a therapeutic agent for MERS containing the same as an active component. A compound containing the

Synthesizing method of isoamylene-based chalcone derivative and application of isoamylene-based chalcone derivative in pharmaceutical industry

The invention discloses a synthesizing method of an isoamylene-based chalcone derivative and application of the isoamylene-based chalcone derivative in pharmaceutical industry. The derivative involvedin the method is synthesized in the steps that 1, a com

Bavachinin analogues as agonists of pan-peroxisome proliferator-activated receptors

Peroxisome proliferator-activated receptors (PPARs) agonists contribute to the regulation of glucose, lipid, and cholesterol metabolism and have emerged as key targets to treat metabolic syndrome. In our previous study, the natural compound bavachinin was found to have pan-PPAR agonist activity. In this study, five isoflavones, three isoflavanones, and five scaffold-hopping analogues of bavachinin were designed, synthesised, and evaluated through reporter gene assays for pan-PPAR agonist activity. The analogue 2-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-2,3-dihydroquinolin-4(1H)-one (21) was identified as a pan-PPAR agonist, exhibiting substantially higher PPAR α/β agonist activity and equal PPAR-γ agonist activity than does bavachinin.

A restorative Psoralea corylifolia active component in the synthesis of the key intermediate (by machine translation)

The invention relates to a fruit hyperuricemia active component in the synthesis of the key intermediate, comprising the following steps: (a) will be Paeonia suffruticosa Andr. (tree peony bark) phenol, 1 - bromo - 3 - methyl - 2 - butene and acetone mixe

Method for synthesizing active ingredient intermediate of traditional Chinese medicine fructus psoraleae

The invention relates to a method for synthesizing an active ingredient intermediate of a traditional Chinese medicine fructus psoraleae. The method comprises the following steps: (a) mixing paeonol,1-bromo-3-methyl-2-butene and acetone, and adding potass

Synthesis method of active component of Chinese herb psoralea corylifolia

The invention relates to a synthesis method of an active component of a Chinese herb psoralea corylifolia. The synthesis method comprises the following steps: (a), mixing paeonol, 1-bromo-3-methyl-2-butene and acetone, adding potassium carbonate, and then

Design, Synthesis, and Structure–Activity Relationships of Bavachinin Analogues as Peroxisome Proliferator-Activated Receptor γ Agonists

Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been used for the treatment of diabetes with the effect of lowering blood glucose levels and improving insulin sensitivity. Natural compounds such as flavones, flavanones, and isoflavones

Separation and peroxisome proliferator-activated receptor-γ agonist activity evaluation of synthetic racemic bavachinin enantiomers

Abstract Bavachinin, isolated from Psoralea corylifolia seeds, has been reported to demonstrate peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist activity. However, isolated bavachinin is actually a mixture of S and R configurations, with an e

Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation

The discovery of potent inhibitors of prostaglandin E2 (PGE 2) synthesis in recent years has been proven to be an important game changer in pharmaceutical industry. It is known that excessive production of PGE2 triggers a

Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.