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20784-60-5

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20784-60-5 Usage

Description

1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one, commonly known as parthenolide, is a naturally occurring sesquiterpene lactone compound found in the plant feverfew. It exhibits a range of biological activities, including anti-inflammatory, anti-cancer, and neuroprotective properties. Parthenolide has garnered interest for its potential therapeutic applications in treating migraines, arthritis, and various forms of cancer. However, further research is necessary to fully elucidate its mechanisms of action and establish its safety and efficacy profile.

Uses

Used in Pharmaceutical Industry:
Parthenolide is used as a potential therapeutic agent for various inflammatory and autoimmune conditions due to its anti-inflammatory properties. It modulates the activity of inflammatory mediators and immune cells, offering a promising approach to managing inflammation-related disorders.
Used in Cancer Treatment:
In the oncology field, parthenolide is utilized as a potential anti-cancer agent. It has been studied for its ability to induce apoptosis in cancer cells, inhibit cell proliferation, and modulate signaling pathways involved in tumor growth and progression. Its potential synergistic effects with conventional chemotherapeutic drugs are also being explored to enhance treatment outcomes in cancer patients.
Used in Neuroprotection:
Parthenolide is employed as a neuroprotective agent in the context of neurodegenerative diseases. Its neuroprotective properties are attributed to its ability to modulate inflammatory processes, oxidative stress, and neuronal cell death, offering a potential therapeutic strategy for conditions such as Alzheimer's disease and Parkinson's disease.

Check Digit Verification of cas no

The CAS Registry Mumber 20784-60-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,7,8 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 20784-60:
(7*2)+(6*0)+(5*7)+(4*8)+(3*4)+(2*6)+(1*0)=105
105 % 10 = 5
So 20784-60-5 is a valid CAS Registry Number.

20784-60-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4 -hydroxyphenyl)-2-propen-1-one

1.2 Other means of identification

Product number -
Other names batracyclin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20784-60-5 SDS

20784-60-5Relevant articles and documents

Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents

Gupta, Nidhi,Qayum, Arem,Raina, Arun,Shankar, Ravi,Gairola, Sumeet,Singh, Shashank,Sangwan, Payare L.

, p. 511 - 523 (2018)

A library of 28 analogs of bavachinin including aliphatic and aromatic ethers, epoxide, chalcone, oxime, semicarbazide, oxime ether and triazole derivatives have been synthesized and evaluated for cytotoxicity against four different human cancer cell lines. Bio-evaluation studies exhibited better cytotoxic profile for many analogs compare to bavachinin. Best results were observed for a 1,2,3-triazole analog (17i) with IC50 values 7.72, 16.08, 7.13 and 11.67 μM against lung (A549), prostate (PC-3), colon (HCT-116) and breast (MCF-7) cancer cell lines respectively. This analog showed three and four fold improvement in cytotoxicity against HCT-116 and A549 cell lines than parent molecule (1). Structure activity relationship (SAR) study for all synthesized analogs was carried out. Further, mechanistic study of the lead molecule (17i) revealed that it inhibits colony formation and in vitro migration of human colon cancer cells (HCT-116). Also, it induced the morphological changes and mediated the apoptotic cell death of HCT-116 cells with perturbance in mitochondrial membrane potential (MMP) and PARP cleavage.

THERAPEUTIC AGENT

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Page/Page column 59, (2010/11/08)

A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.

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