284480-89-3

Upstream product

• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 185030-60-8 (R)-methyl 3-((4-methoxybenzyl)oxy)butanoate 

Downstream Products

• 155581-28-5 (R)-3-((4-methoxybenzyl)oxy)-1-butanal 
• 284480-96-2 Toluene-4-sulfonic acid (3E,5E)-(2S,10R)-2-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-undeca-3,5-dienyl ester 
• 284480-91-7 (S)-4-[(1E,3E)-(R)-6-Benzenesulfonyl-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxolane 
• 284480-94-0 Toluene-4-sulfonic acid (3E,5E)-(2S,10R)-2-hydroxy-10-(4-methoxy-benzyloxy)-undeca-3,5-dienyl ester 
• 284480-93-9 (3E,5E)-(2S,10R)-10-(4-Methoxy-benzyloxy)-undeca-3,5-diene-1,2-diol 
• 284480-92-8 (S)-4-[(1E,3E)-(R)-8-(4-Methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxolane 
• 284480-77-9 1-((R)-3-Benzenesulfonyl-1-methyl-propoxymethyl)-4-methoxy-benzene 
• 284480-90-6 1-((R)-3-Iodo-1-methyl-propoxymethyl)-4-methoxy-benzene 

Relevant academic research and scientific papers

A synthetic natural product Tarchonanthuslactone isomer of

The invention provides a method for synthesizing a natural product Tarchonanthuslactone isomer. According to the method, methyl-3-hydroxybutyrate is used as a raw material, and PMB ester protection, LiALH4 reduction, Swern oxidation, Mukaiyama Aldol reaction, ester hydrolysis, Yanaguchi cyclization, de-protection and condensation are performed, so that the natural product Tarchonanthuslactone isomer is obtained. The synthetic route is novel and reasonable in design, the raw materials are cheap and easy to obtain, the operation process is simple and convenient, the reaction condition is mild, the rate is high, side reaction is less, the operation is simple and convenient, and the synthesizing cost is greatly reduced.

Studies on the total synthesis of macrolactin A. A stereoselective synthesis of the C3-C13 and C14-C24 fragments

Synthetic studies towards the C3-C13 (2) and C14-C24 (3) segments of the potent antiviral and antitumor compound macrolactin A (1) are presented. Segment 2 was constructed via a convergent and facile approach, exploiting Wittig olefination to generate the sensitive E,Z-diene-moiety. Segment 3 was obtained from the chiral pool derived sulfone 4 via an α- alkylation-desulfonation reaction sequence. (C) 2000 Elsevier Science Ltd.