284480-93-9

Upstream product

• 185030-60-8 (R)-methyl 3-((4-methoxybenzyl)oxy)butanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 284480-92-8 (S)-4-[(1E,3E)-(R)-8-(4-Methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxolane 
• 284480-91-7 (S)-4-[(1E,3E)-(R)-6-Benzenesulfonyl-8-(4-methoxy-benzyloxy)-nona-1,3-dienyl]-2,2-dimethyl-[1,3]dioxolane 
• 284480-77-9 1-((R)-3-Benzenesulfonyl-1-methyl-propoxymethyl)-4-methoxy-benzene 
• 284480-90-6 1-((R)-3-Iodo-1-methyl-propoxymethyl)-4-methoxy-benzene 
• 284480-89-3 (R)-3-((4-methoxybenzyl)oxy)-1-butanol 
• 185025-32-5 (2E,4E)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-penta-2,4-dienoic acid ethyl ester 
• 284480-78-0 (S)-4-((1E,3E)-5-Bromo-penta-1,3-dienyl)-2,2-dimethyl-[1,3]dioxolane 
• 185025-33-6 (2E,4E)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-penta-2,4-dien-1-ol 

Downstream Products

• 284480-94-0 Toluene-4-sulfonic acid (3E,5E)-(2S,10R)-2-hydroxy-10-(4-methoxy-benzyloxy)-undeca-3,5-dienyl ester 
• 284480-96-2 Toluene-4-sulfonic acid (3E,5E)-(2S,10R)-2-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-undeca-3,5-dienyl ester 

Relevant academic research and scientific papers

Studies on the total synthesis of macrolactin A. A stereoselective synthesis of the C3-C13 and C14-C24 fragments

Synthetic studies towards the C3-C13 (2) and C14-C24 (3) segments of the potent antiviral and antitumor compound macrolactin A (1) are presented. Segment 2 was constructed via a convergent and facile approach, exploiting Wittig olefination to generate the sensitive E,Z-diene-moiety. Segment 3 was obtained from the chiral pool derived sulfone 4 via an α- alkylation-desulfonation reaction sequence. (C) 2000 Elsevier Science Ltd.