284486-62-0Relevant academic research and scientific papers
Straightforward and diastereoselective synthesis of tetrafunctionalized thiol synthons for the design of metallopeptidase inhibitors
David, Christelle,Bischoff, Laurent,Roques, Bernard P.,Fournié-Zaluski, Marie-Claude
, p. 209 - 215 (2000)
Tetrafunctionalized thiol-containing synthons with different side-chains have been prepared with good yields by a straightforward diastereoselective and general methodology. The key step of the synthesis consisted of a tandem reduction and Wittig-Horner r
Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme
David, Christelle,Bischoff, Laurent,Meudal, Hervé,Mothé, Aurélie,De Mota, Nadia,DaNascimento, Sophie,Llorens-Cortes, Catherine,Fournié-Zaluski, Marie-Claude,Roques, Bernard P.
, p. 5197 - 5211 (2007/10/03)
The study of the physiological roles of the membrane-bound zinc- aminopeptidase A (glutamyl aminopeptidase, EC 3.4.11.7) needs the design of efficient and selective inhibitors of this enzyme. An acute exploration of aminopeptidase A active site was perfor
