284496-13-5Relevant academic research and scientific papers
Synthesis of 2-acyl- and 2-ethoxycarbonyl-3-alkylindoles from o-alkynyltrifluoroacetanilides
Arcadi, Antonio,Cacchi, Sandro,Fabrizi, Giancarlo,Marinelli, Fabio
, p. 647 - 649 (2007/10/03)
The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or α-bromoke-tones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process. Thieme Stuttgart.
The palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with alkyl halides. An entry into 2-substituted 3-alkylindoles
Arcadi, Antonio,Cacchi, Sandro,Fabrizi, Giancarlo,Marinelli, Fabio
, p. 394 - 396 (2007/10/03)
Indolylcarboxylate esters 2 and 2-substituted-3-benzylindoles 4 are prepared usually in good yield through the palladium-catalyzed reaction of o- alkynyltrifluoro acetanilides with ethyl iodoacetate or benzyl bromide. Best results are obtained by employing Pd2(dba)3 and tris(2,4,6- trimethoxyphenyl)phosphine in THF.
