284660-89-5

Upstream product

• 284660-88-4 methyl 5-[(trifluoromethyl)sulfonyloxy]indole-2-carboxylate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1411992-60-3 C₃₂H₄₂BN₃O₅ 
• 284660-86-2 methyl 5-boronyl-indole-2-carboxylate 

Relevant academic research and scientific papers

MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME

Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

Bicyclic compositions and methods for modulating a kinase cascade

The invention relates to compounds and methods for modulating one or more components of a kinase cascade.

Kinase inhibitors

The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced usi