284665-18-5

Basic information

• Product Name: D-METHIONINE-D3 (S-METHYL-D3)
• Synonyms: D-Methionine-d3;D-Methionine-d3 (methyl-d3)
• CAS NO: 284665-18-5
• Molecular Formula: C5H8D3NO2S
• Molecular Weight: 152.231
• Mol File: 284665-18-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-METHIONINE-D3 (S-METHYL-D3)(CAS DataBase Reference)
• NIST Chemistry Reference: D-METHIONINE-D3 (S-METHYL-D3)(284665-18-5)
• EPA Substance Registry System: D-METHIONINE-D3 (S-METHYL-D3)(284665-18-5)

Safety Data

• Hazardous Substances Data: 284665-18-5(Hazardous Substances Data)

Usage

Description

D-METHIONINE-D3 (S-METHYL-D3) is a stable isotope-labeled amino acid derivative, specifically a deuterated form of D-methionine. It is characterized by the presence of three deuterium atoms (D3) in the methyl group, which distinguishes it from its non-labeled counterpart. This unique property allows for the accurate detection and quantification of D-methionine in various biological samples.

Uses

Used in Analytical Chemistry:
D-METHIONINE-D3 (S-METHYL-D3) is used as an internal standard for the detection and quantification of Dand L-enantiomers of methionine and [2H3]methionine in plasma samples. The application reason is to enhance the accuracy and precision of gas chromatography-mass spectrometry (GC-MS) analysis by providing a reference point for the measurement of endogenous methionine levels.
Used in Pharmaceutical Research:
In the pharmaceutical industry, D-METHIONINE-D3 (S-METHYL-D3) can be used as a research tool for studying the metabolism and pharmacokinetics of methionine. The application reason is to better understand the role of methionine in various biological processes and its potential as a therapeutic target for drug development.
Used in Clinical Diagnostics:
D-METHIONINE-D3 (S-METHYL-D3) can be employed in clinical diagnostics as a diagnostic aid for various conditions related to methionine metabolism. The application reason is to provide a reliable and accurate method for monitoring methionine levels in patients, which can be crucial for the diagnosis and management of certain metabolic disorders.

Upstream product

• 331665-05-5 C₅H₄⁽²⁾H₇NO₂S 
• 93709-61-6 DL-[3,3,4,4-⁽²⁾H₄]methionine 
• 331665-06-6 C₇H₆⁽²⁾H₇NO₃S 
• 865-50-9 iodomethane-d3 
• 78496-74-9 (4R)-L-<4-2H>homocysteine 
• 78496-74-9 (4S)-L-<4-2H>homocysteine 
• 626-72-2 L-homocystine 
• 20710-47-8 [13C₂H₃] methyl iodide 
• 18265-50-4 DL-homocysteine thiolactone hydrochloride 

Downstream Products

• 521-03-9 22-dihydrochondrillasterol 
• 6785-58-6 22-dihydro-25-dehydrochondrillasterol 

Relevant articles and documents

Method for efficiently preparing deuterated iodomethane and application of deuterated iodomethane

The invention discloses a method for efficiently preparing deuterated iodomethane and an application of the deuterated iodomethane; according to the method, deuterated methanol and iodine elementary substance are used as reaction raw materials, in a hydrogen atmosphere, a transition metal catalyst and a ligand are added, and the deuterated iodomethane is generated in situ at the temperature of 0 DEG C-120 DEG C. The application is the application of deuterated iodomethane as a methylation reagent in preparation of S-(methyl-D3)homocysteine, and mainly comprises the steps: carrying out methylation reaction on a compound a, namely (t-butyloxycarboryl)-L-homocysteine methyl ester and deuterated iodomethane in an organic solvent under the action of a base catalyst to obtain a product b; and performing deprotection on the product b to obtain a target product c, namely S-(methyl-D3)homocysteine. Anhydrous hydrogen iodide is prepared through catalysis of a transition metal catalyst, the anhydrous hydrogen iodide and deuterated methanol directly react through a one-pot method to obtain deuterated iodomethane with the high yield (88%), and the deuterated iodomethane serves as a deuterated methyl reagent to prepare S-(methyl-D3)homocysteine with the high deuterium doping rate and the yield (75%). The method is simple and easy to operate, and reaction conditions are mild.

Rationally engineered variants of S-adenosylmethionine (SAM) synthase: Reduced product inhibition and synthesis of artificial cofactor homologues

S-Adenosylmethionine (SAM) synthase was engineered for biocatalytic production of SAM and long-chain analogues by rational re-design. Substitution of two conserved isoleucine residues extended the substrate spectrum of the enzyme to artificial S-alkylhomocysteines. The variants proved to be beneficial in preparative synthesis of SAM (and analogues) due to a much reduced product inhibition. This journal is

Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus

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