331665-05-5

Basic information

• Product Name: C₅H₄⁽²⁾H₇NO₂S
• CAS NO: 331665-05-5
• Molecular Weight: 156.158
• Mol File: 331665-05-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅H₄⁽²⁾H₇NO₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₅H₄⁽²⁾H₇NO₂S(331665-05-5)
• EPA Substance Registry System: C₅H₄⁽²⁾H₇NO₂S(331665-05-5)

Safety Data

• Hazardous Substances Data: 331665-05-5(Hazardous Substances Data)

Upstream product

• 865-50-9 iodomethane-d3 
• 93709-61-6 DL-[3,3,4,4-⁽²⁾H₄]methionine 

Downstream Products

• 284665-18-5 L-[3,3,4,4,S-methyl-2H7]methionine 

Relevant articles and documents

Synthesis of L-[3,3,4,4,S-methyl-2H7]methionine for use as a substrate for the methionine loading test

Optically pure L-[3,3,4,4,S-methyl-2H7]methionine (L-[2H7]methionine) for use as a substrate for the methionine loading test has been prepared. The racemic [2H7]methionine was prepared from DL-[3,3,4,4-2H4]methionine (DL-[2H4]methionine) by conversion of the S-CH3 group to a C2H3 group. The racemate was resolved by stereospecific hydrolysis of the N-acetylated derivative with acylase. After an intravenous administration of L-[2H7]methionine in a rat, the concentration of L-[2H7]methionine and the metabolites in plasma were determined by GC-MS-SIM. L-[2H4]Homocysteine and L-[2H4]methionine were detected in plasma at 30 min after dosing. These results show that L-[2H7]methionine was converted by de-methylation and subsequent remethylation to form L-[2H4] methionine.