284665-40-3

Basic information

• Product Name: 4-(3,5-BIS-TRIFLUOROMETHYLPHENYL)THIAZOL-2-YLAMINE
• Synonyms: BUTTPARK 41\03-38;4-(3,5-BIS-TRIFLUOROMETHYLPHENYL)THIAZOL-2-YLAMINE;2-Amino-4-(3,5-bis(trifluoromethyl)phenyl)thiazole;4-(3,5-Bis(trifluoromethyl)phenyl)thiazol-2-amine;4-[3,5-bis(trifluoroMethyl)phenyl]-1,3-thiazol-2-aMine
• CAS NO: 284665-40-3
• Molecular Formula: C₁₁H₆F₆N₂S
• Molecular Weight: 312.23
• Mol File: 284665-40-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 146.3-147.6°C
• Boiling Point: 338.793 °C at 760 mmHg
• Flash Point: 158.697 °C
• Appearance: /
• Density: 1.51 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(3,5-BIS-TRIFLUOROMETHYLPHENYL)THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,5-BIS-TRIFLUOROMETHYLPHENYL)THIAZOL-2-YLAMINE(284665-40-3)
• EPA Substance Registry System: 4-(3,5-BIS-TRIFLUOROMETHYLPHENYL)THIAZOL-2-YLAMINE(284665-40-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 284665-40-3(Hazardous Substances Data)

Usage

General Description

4-(3,5-Bis-Trifluoromethylphenyl)thiazol-2-ylamine is a chemical compound with the molecular formula C12H8F6N2S. It belongs to the thiazole class of compounds and contains a thiazole ring with an attached amine group. The compound is characterized by the presence of two trifluoromethylphenyl groups, which contribute to its strong electron-withdrawing and lipophilic properties. This chemical structure has potential applications in pharmaceuticals and agrochemicals due to its ability to bind to specific biological targets and its favorable physicochemical properties. The compound may be utilized in drug discovery and development efforts to create novel therapeutics with improved pharmacokinetic and pharmacodynamic profiles. Additionally, it may also have applications in the development of new crop protection products due to its potential as a pesticide or fungicide.

Upstream product

• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 17356-08-0 thiourea 

Relevant articles and documents

THERAPEUTIC AGENT FOR CANCER

A medicament for the prevention and/or treatment of cancers and the like which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1? a fused polycyclic heteroaryl group wherein the ring which binds directly to ―CONH― group in the formula (I) is a benzene ring, 2? unsubstituted thiazol-2-yl group, or 3? unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ―CONH―E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ― CONH―E wherein E has the same meaning as that defined above.

INHIBITORS AGAINST THE ACTIVATION OF AP-1 AND NFAT

A medicament inhibiting the activation of AP-1 which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above.