284680-44-0Relevant academic research and scientific papers
Synthesis and Biological Activity of New 2-{[6-Methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl]oxy}acetohydrazide Derivatives
Pivazyan,Ghazaryan,Azaryan, Zh. A.,Yengoyan
, p. 2010 - 2017 (2019)
The reaction of 6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4(3H)-one with methyl chloroacetate, followed by hydrazinolysis, gave 2-{[6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl]oxy}acetohydrazide, and the latter was used to obtain a series of new derivatives, i
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases
Linz, Sabine,Mueller, Joerg,Huebner, Harald,Gmeiner, Peter,Troschuetz, Reinhard
experimental part, p. 4448 - 4458 (2009/12/04)
A series of phenylpiperazine-methyl-substituted 1H-pyrrolo[2,3-c]pyridine, imidazo[1,2-c]-, pyrrolo[2,3-d]- and pyrrolo[3,2-d]pyrimidines were prepared as selective dopamine D4-ligands. The pyrrolo[2,3-d]pyrimidine derivatives 12d (Ki = 1,9 nM)
