28469-23-0

Usage

Chemical structure

4-nitro-1-(2-phenylethyl)-1H-pyrazole consists of a pyrazole ring with a nitro group at the 4-position and a phenylethyl group attached at the 1-position.

Usage in pharmaceutical research

It is commonly used as a building block for the synthesis of various organic compounds.

Pharmacological properties

The molecule has been studied for its potential pharmacological properties, including anti-inflammatory, analgesic, and anti-cancer activities.

Therapeutic potential

It has been investigated as a potential therapeutic agent for various medical conditions.

Chemical reactivity

The chemical structure and reactivity of the compound make it useful in organic synthesis for the creation of novel compounds with diverse biological activities.

Upstream product

• 2075-46-9 4-nitro-1H-pyrazole 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 1584233-62-4 4-nitro-1-(2-phenylethyl)-5-[3-(trifluoromethyl)phenyl]-1H-pyrazole 
• 1584233-79-3 4-nitro-3,5-bis(3-nitrophenyl)-1-phenethyl-1H-pyrazole 
• 1584233-63-5 4-nitro-5-(3-nitrophenyl)-1-phenethyl-1H-pyrazol 
• 28466-65-1 1-phenethyl-1H-pyrazol-4-amine 

Relevant academic research and scientific papers

AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS

The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.

Regioselective and guided C-H activation of 4-nitropyrazoles

A divergent and regioselective approach to 5-aryl-4-nitro-1H-pyrazoles was developed by guided transition-metal-catalyzed arylation of 4-nitro-1H- pyrazoles. This method provides a convenient tool for the functionalization of the pharmacologically relevan

NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS

The present invention relates to pyrazole and imidazole derivatives of formula (I) wherein U, V, L, X, Y, R1, (R2)n and (R3)m and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2