28482-04-4

Upstream product

• 592-41-6 1-hexene 
• 1577-22-6 5-hexenoic acid 
• 88663-39-2 non-4-ynoic acid 
• 6089-09-4 4-pentynoic acid 
• 18187-17-2 2-trimethylsilanyl-acrylic acid 
• 62839-68-3 C₆H₁₁Li 

Relevant academic research and scientific papers

Iridium-catalyzed enantioselective hydroalkynylation via alkene isomerization

An iridium-catalyzed enantioselective alkynylation of methylene C–H bonds γ to the amide group is developed. The reaction proceeds through alkene isomerization followed by regioselective hydroalkynylation. This method provides rapid access to a wide range of stereodefined alkynylated compounds in good yields and good enantioselectivities.

BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS

The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Self-Protection: The Advantage of Radical Oligomeric Mixtures in Organic Synthesis

Atom-transfer radical oligomers of allyl iodoacetates were converted to 4-pentenoic acids upon treatment with zinc. Reactions of the radical oligomers of various ω-alkenyl iodoacetates with Grignard reagents afforded the corresponding substituted tetrahydrofuran derivatives. These results indicated that radical oligomeric mixtures not only serve as versatile intermediates in organic synthesis, but also exhibit unique advantages in that the oligomeric mixtures are self-protected and the deoligomerization functions as the simultaneous deprotection.