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28488-51-9

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28488-51-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 28488-51-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,4,8 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 28488-51:
(7*2)+(6*8)+(5*4)+(4*8)+(3*8)+(2*5)+(1*1)=149
149 % 10 = 9
So 28488-51-9 is a valid CAS Registry Number.

28488-51-9Relevant articles and documents

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

Wapenaar, Hannah,Van Der Wouden, Petra E.,Groves, Matthew R.,Rotili, Dante,Mai, Antonello,Dekker, Frank J.

supporting information, p. 289 - 296 (2015/11/09)

Lysine acetyltransferase 8 (KAT8) is a histone acetyltransferase (HAT) responsible for acetylating lysine 16 on histone H4 (H4K16) and plays a role in cell cycle progression as well as acetylation of the tumor suppressor protein p53. Further studies on its biological function and drug discovery initiatives will benefit from the development of small molecule inhibitors for this enzyme. As a first step towards this aim we investigated the enzyme kinetics of this bi-substrate enzyme. The kinetic experiments indicate a ping-pong mechanism in which the enzyme binds Ac-CoA first, followed by binding of the histone substrate. This mechanism is supported by affinity measurements of both substrates using isothermal titration calorimetry (ITC). Using this information, the KAT8 inhibition of a focused compound collection around the non-selective HAT inhibitor anacardic acid has been investigated. Kinetic studies with anacardic acid were performed, based on which a model for the catalytic activity of KAT8 and the inhibitory action of anacardic acid (AA) was proposed. This enabled the calculation of the inhibition constant Ki of anacardic acid derivatives using an adaptation of the Cheng-Prusoff equation. The results described in this study give insight into the catalytic mechanism of KAT8 and present the first well-characterized small-molecule inhibitors for this HAT.

Synthesis of Lipophilic Crown Ethers with Pendant Carboxylic Acid Groups

Czech, Bronislaw P.,Czech, Anna,Son, Byungki,Lee, Han Koo,Bartsch, Richard A.

, p. 465 - 471 (2007/10/02)

Synthetic routes to thirteen highly lipophilic crown ether carboxylic acids are described.Seven contain 12-15-membered crown ether units with four ring oxygens and are designed for lithium ion complexation.Three others possess large ring 24-crown-8,27-cro

Potential salicylamide antiplaque agents: In vitro antibacterial activity against Actinomyces viscosus

Coburn,Batista,Evans,Genco

, p. 1245 - 1249 (2007/10/02)

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