28490-56-4

Usage

Uses

Used in Organic Synthesis:
5-Fluoro-2-iodotoluene is utilized as a key building block in the synthesis of a diverse array of organic compounds. Its unique combination of fluoro and iodo groups allows for a wide range of chemical reactions, making it a valuable component in the creation of new molecules with specific properties.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-Fluoro-2-iodotoluene serves as an essential precursor in the development of new drugs. Its structural features contribute to the design of pharmaceutical agents with improved efficacy and selectivity, playing a crucial role in drug discovery and optimization processes.
Used in Drug Discovery:
5-Fluoro-2-iodotoluene is employed as a starting material in the exploration of novel drug candidates. Its potential application in drug discovery is attributed to its ability to be modified and functionalized, facilitating the creation of compounds with desired biological activities and therapeutic potentials.
Used in Chemical Research:
5-Fluoro-2-iodotoluene is also used in academic and industrial chemical research to study the effects of halogenated groups on chemical reactivity and stability. Understanding these effects can lead to advancements in the design of new chemical processes and materials.

Upstream product

• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 456-47-3 3-fluoro-benzenemethanol 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 2408-08-4 (3-fluorobenzyl)(trifluoromethyl)sulfane 
• 136794-75-7 4'-O-demethyl-4β-[(3''-fluorobenzyl)amino]-4-desoxypodophyllotoxin 
• 352-70-5 m-Fluorotoluene 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 456-42-8 m-fluorobenzyl chloride 
• 690969-16-5 {4-[(3-fluorobenzyl)oxy]phenyl}methanol 
• 202825-46-5 safinamide mesylate 
• 133865-89-1 safinamide 
• 2408-22-2 3-fluorophenylmethyl trifluoromethyl sulfone 
• 2408-07-3 (3-Fluor-benzyl)-trifluormethyl-sulfoxid 

Relevant academic research and scientific papers

A new enantioselective synthesis of the anti-Parkinson agent safinamide

An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from simple, commercially available, starting materials is described. The protocol might also be useful in the synthesis of structural variants of safinamide, such as ralfinamide or related analogues. Georg Thieme Verlag Stuttgart New York.

AN IMPROVED SYNTHESIS OF ANTI-PARKINSON AGENT

The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R1 and R2 are each independently selected from hydrogen or halogen.

Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyollotoxin as potent inhibitors of human DNA topoisomerase II

A number of new 4'-O-demethylepipodophyllotoxin derivatives possessing various 4β-N- or 4β-O-benzyl groups have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-linked DNA breakage. The 4β-N-benzyl derivatives 9-22 are, in general, as active or more active than etoposide (1). The most active compounds are 14, 16, and 17, which are more than 2-fold more potent than 1. The results indicated that a basic unsubstituted 4β-benzylamino moiety is structurally required for the enhanced activity. Replacement of the benzyl nitrogen with oxygen gave compounds (23 and 24) which are inactive. The ability of these compounds to inhibit human DNA topoisomerase II and to cause protein-linked DNA breakage appears to have no direct correlation with cytotoxicity in KB cells.

Carbon-Halogen Bonding Studies. Halogen Redistribution Reactions between Alkyl or Acetyl Halides and Tri-n-butyltin Halides

The equilibrium positions have been determined for the halogen redistribution reactions of tri-n-butyltin halides with a variety of structurally different types of alkyl halides and with acetyl halides.These have been related through the reaction ΔGo values to carbon-halogen bond dissociation energy differences.It is suggested that the trends observed in the latter may provide evidence for the existence of a small steric bond weakening effect in the order C-I > C-Br > C-Cl bonds on going from methyl to primary, secondary, and tertiary alkyl halides.On the other hand, with the 2,3-? bond containing allyl, benzyl, and propargyl halides , α-haloacetones, and haloacetonitriles, there may be some type of electronic carbon-halogen bond strengthening effect which lies in order C-I > C-Br > C-Cl.Finally, for the acetyl halides, the data are in agreement with increases in bond strengths resulting from ? contributions being in the order C-Cl > C-Br > C-I.